tlr9 toll-like receptor 9 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tlr9provided by ZNC
Official Full Name: toll-like receptor 9provided by ZNC
Primary source: ZFIN:ZDB-GENE-040219-10
See related: Ensembl:ENSDARG00000044490 AllianceGenome:ZFIN:ZDB-GENE-040219-10
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu392
Summary: Predicted to enable pattern recognition receptor activity. Acts upstream of or within antibacterial humoral response and toll-like receptor signaling pathway. Located in endoplasmic reticulum. Is expressed in blood; heart; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Orthologous to human TLR9 (toll like receptor 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (53730368..53733659, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (53900648..53903939, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that zebTLR9 and zebTLR21 cooperatively mediate the antimicrobial activities of CpG-ODN. Overall, this study provides a molecular basis for the activities of CpG-ODN in fish.
Title: Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 9

Names: TIR9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130594.1 → NP_001124066.1 toll-like receptor 9 precursor

See identical proteins and their annotated locations for NP_001124066.1

Status: PROVISIONAL

Source sequence(s)

BC163628

UniProtKB/TrEMBL

B3DJW3

Related

ENSDARP00000105677.2, ENSDART00000124218.3

Conserved Domains (4) summary

cd00116
Location:73 → 312

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:39 → 57

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:56 → 129

LRR_8; Leucine rich repeat

cl23749
Location:894 → 1040

TIR_2; TIR domain