tlr1 toll-like receptor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tlr1provided by ZNC
Official Full Name: toll-like receptor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040220-1
See related: Ensembl:ENSDARG00000100649 AllianceGenome:ZFIN:ZDB-GENE-040220-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Predicted to act upstream of or within innate immune response; positive regulation of inflammatory response; and toll-like receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (732606..736575, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (714224..718193, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations
Title: Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 1

Names: TIR1.2; tlr6

NP_001124065.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130593.1 → NP_001124065.1 toll-like receptor 1

See identical proteins and their annotated locations for NP_001124065.1

Status: PROVISIONAL

Source sequence(s)

BC163271

UniProtKB/TrEMBL

B3DIW3

Related

ENSDARP00000139386.1, ENSDART00000168611.2

Conserved Domains (4) summary

smart00255
Location:642 → 783

TIR; Toll - interleukin 1 - resistance

sd00033
Location:346 → 373

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:46 → 106

LRR_8; Leucine rich repeat

cl15307
Location:524 → 565

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain