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tlr3 toll-like receptor 3 [ Danio rerio (zebrafish) ]

Gene ID: 403126, updated on 19-Jan-2025

Summary

Official Symbol
tlr3provided by ZNC
Official Full Name
toll-like receptor 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040219-7
See related
Ensembl:ENSDARG00000016065 AllianceGenome:ZFIN:ZDB-GENE-040219-7
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:123006
Summary
Predicted to enable signaling receptor activity. Acts upstream of or within response to bacterium and response to virus. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; central nervous system; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See tlr3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (17892944..17898227)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (17200007..17205290)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:dkey-256e7.8 Neighboring gene PDZ and LIM domain 3a Neighboring gene sorbin and SH3 domain containing 2a Neighboring gene cytochrome P450, family 4, subfamily V, member 2a Neighboring gene uncharacterized LOC101885541

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC123006

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding PubMed 
enables signaling receptor activity  
enables transmembrane signaling receptor activity  
Component Evidence Code Pubs
located_in membrane  
is_active_in plasma membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013269.3NP_001013287.2  toll-like receptor 3 precursor

    See identical proteins and their annotated locations for NP_001013287.2

    Status: PROVISIONAL

    Source sequence(s)
    BC107955
    UniProtKB/TrEMBL
    Q32PW5
    Related
    ENSDARP00000014779.8, ENSDART00000013021.9
    Conserved Domains (5) summary
    smart00082
    Location:645683
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756898
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:49183
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:355378
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:562622
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    17892944..17898227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394471.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    238623..243906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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