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tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 403084, updated on 27-Mar-2024

Summary

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Official Symbol
tab1provided by ZNC
Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060628-1
See related
Ensembl:ENSDARG00000036613 AllianceGenome:ZFIN:ZDB-GENE-060628-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
map3k7ip1
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to act upstream of or within NIK/NF-kappaB signaling. Predicted to be active in cytosol and nucleus. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (181133..185607)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (163082..167556)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene LYL1 basic helix-loop-helix family member Neighboring gene GTPase IMAP family member 6 Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b Neighboring gene C1q and TNF related 6b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. TAK1-binding proteins (TAB1 and TAB2) in grass carp (Ctenopharyngodon idella): identification, characterization, and expression analysis after infection with Ichthyophthirius multifiliis. Zhao F, et al. Fish Shellfish Immunol, 2014 Jun. PMID 24747054
  2. MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Zhou W, et al. Cell Rep, 2018 Feb 13. PMID 29444433, Free PMC Article
  3. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  4. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neutrophil chemotaxis IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within non-canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Names
TAK1-binding protein 1
mitogen-activated protein kinase kinase kinase 7 interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    181133..185607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002662240.6 → XP_002662286.4  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

    UniProtKB/TrEMBL
    A0A8M1RLT6
    Related
    ENSDARP00000053182.6, ENSDART00000053183.6
    Conserved Domains (1) summary
    cd00143
    Location:26 → 327
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein Strain
Heading Accession and Version

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