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map2k4a mitogen-activated protein kinase kinase 4a [ Danio rerio (zebrafish) ]

Gene ID: 403052, updated on 27-Mar-2024

Summary

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Official Symbol
map2k4aprovided by ZNC
Official Full Name
mitogen-activated protein kinase kinase 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060512-98
See related
Ensembl:ENSDARG00000063583 AllianceGenome:ZFIN:ZDB-GENE-060512-98
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MKK4; map2k4; MKK4A-l; zgc:136500
Summary
Predicted to enable JUN kinase kinase activity. Involved in JNK cascade. Acts upstream of or within determination of dorsal identity. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See map2k4a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (10592597..10634531, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (10626051..10667999, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 100a Neighboring gene elaC ribonuclease Z 2 Neighboring gene uncharacterized LOC110438746 Neighboring gene transmembrane protein 220

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Chou CM, et al. J Biomed Sci, 2015 Nov 17. PMID 26572230, Free PMC Article
  2. The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage. Baek S, et al. Dev Cell, 2019 Apr 22. PMID 31014480
  3. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Seo J, et al. J Cell Biochem, 2010 Jul 1. PMID 20564202
  4. Aloe emodin induces hepatotoxicity by activating NF-κB inflammatory pathway and P53 apoptosis pathway in zebrafish. Quan Y, et al. Toxicol Lett, 2019 May 15. PMID 30771440
  5. In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae. Díaz-Pascual F, et al. Front Cell Infect Microbiol, 2017. PMID 28791256, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC136500

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4a
Names
mitogen-activated protein kinase kinase 4
mkk4a
NP_991299.2
XP_005164412.1
XP_009297453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205736.2 → NP_991299.2  dual specificity mitogen-activated protein kinase kinase 4a

    See identical proteins and their annotated locations for NP_991299.2

    Status: PROVISIONAL

    Source sequence(s)
    EF433293
    UniProtKB/TrEMBL
    A0A8M1PH96, B1NA68
    Related
    ENSDARP00000106153.1, ENSDART00000130761.4
    Conserved Domains (2) summary
    smart00220
    Location:108 → 372
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:101 → 390
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    10592597..10634531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164355.4 → XP_005164412.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BBT8
    Conserved Domains (2) summary
    smart00220
    Location:93 → 357
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:86 → 375
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

  2. XM_009299178.3 → XP_009297453.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B0Q3
    Conserved Domains (2) summary
    smart00220
    Location:97 → 361
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:90 → 379
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
Nucleotide Protein
Heading Accession and Version

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