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fgf13b fibroblast growth factor 13b [ Danio rerio (zebrafish) ]

Gene ID: 403003, updated on 27-Mar-2024

Summary

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Official Symbol
fgf13bprovided by ZNC
Official Full Name
fibroblast growth factor 13bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1793
See related
Ensembl:ENSDARG00000056633 AllianceGenome:ZFIN:ZDB-GENE-040426-1793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fgf13l; zgc:76868
Summary
Predicted to enable sodium channel regulator activity. Predicted to be involved in regulation of voltage-gated sodium channel activity. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including filopodium; growth cone; and microtubule. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blood; nervous system; neural rod; segmental plate; and trigeminal placode. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See fgf13b in Genome Data Viewer
Location:
chromosome: 10
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (26716616..26744131, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (26754903..26782418, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:ch73-52f15.5 Neighboring gene teleost multiple tissue opsin 3b Neighboring gene proto-oncogene DBL-like Neighboring gene coagulation factor IXb Neighboring gene uncharacterized LOC110438858

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Forward Genetic Screening Using Behavioral Tests in Zebrafish: A Proof of Concept Analysis of Mutants. Gerlai R, et al. Behav Genet, 2017 Jan. PMID 27704300
  2. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Zhu S, et al. Cancer Cell, 2017 Sep 11. PMID 28867147, Free PMC Article
  3. Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species. Heanue TA, et al. Mech Dev, 2008 Aug. PMID 18565740
  4. RNA-sequencing analysis of TCDD-induced responses in zebrafish liver reveals high relatedness to in vivo mammalian models and conserved biological pathways. Li ZH, et al. PLoS One, 2013. PMID 24204792, Free PMC Article
  5. The zebrafish secretome. Klee EW. Zebrafish, 2008 Summer. PMID 18554177, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC76868

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor 13b
Names
fibroblast growth factor 13, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328492.1 → NP_001315421.1  fibroblast growth factor 13b isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    CU468967, CU928122
    UniProtKB/TrEMBL
    A0A8M1P4W4, F6NSV0
    Related
    ENSDARP00000003654.8, ENSDART00000020096.9

  2. NM_001328493.1 → NP_001315422.1  fibroblast growth factor 13b isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    CU468967, CU928122
    UniProtKB/TrEMBL
    A0A0R4IGU4, A0A8M1PA20
    Related
    ENSDARP00000132775.1, ENSDART00000162710.3
    Conserved Domains (1) summary
    smart00442
    Location:22 → 152
    FGF; Acidic and basic fibroblast growth factor family

  3. NM_205702.2 → NP_991265.1  fibroblast growth factor 13b isoform 3

    See identical proteins and their annotated locations for NP_991265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CU468967, CU928122
    UniProtKB/TrEMBL
    A0A8N7V079, Q6NZS6
    Related
    ENSDARP00000150350.1, ENSDART00000188590.1
    Conserved Domains (1) summary
    smart00442
    Location:15 → 145
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    26716616..26744131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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