e2f5 E2F transcription factor 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: e2f5provided by ZNC
Official Full Name: E2F transcription factor 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030828-3
See related: Ensembl:ENSDARG00000038812 AllianceGenome:ZFIN:ZDB-GENE-030828-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: E2F4; cb735; zgc:111879
Summary: Enables DNA-binding transcription factor activity. Acts upstream of or within female somatic sex determination; male meiosis I; and multi-ciliated epithelial cell differentiation. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including Kupffer's vesicle; central nervous system; forerunner cell group; neurogenic placode; and pleuroperitoneal region. Orthologous to human E2F5 (E2F transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (31676788..31686408, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (31693570..31703351, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that E2f5 can function as a versatile transcriptional activator and identify novel roles of the protein in spermatogenesis as well as MCC differentiation during zebrafish development.
Title: E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish.
Transcription factors E2f4 iand E2f5 are required for multiciliogenesis in zebrafish.
Title: E2F4/5-mediated transcriptional control of multiciliated cell differentiation: redundancy or fine-tuning?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within female somatic sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multi-ciliated epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor E2F5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001197300.1 → NP_001184229.1 transcription factor E2F5 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

CK017425, CR293515, EB911484

UniProtKB/TrEMBL

A0A8M1NXA0, A5WUE8

Related

ENSDARP00000056678.6, ENSDART00000056679.8

Conserved Domains (3) summary

COG5665
Location:74 → 328

COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]

cd14660
Location:97 → 201

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:21 → 85

E2F_TDP; E2F/DP family winged-helix DNA-binding domain
NM_205615.2 → NP_991178.1 transcription factor E2F5 isoform 2

See identical proteins and their annotated locations for NP_991178.1

Status: VALIDATED

Description

Transcript Variant: This variant differs in the 3' CDS and 3' UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

CR293515

UniProtKB/TrEMBL

A0A8M1PGG3, Q6TH18

Related

ENSDARP00000111176.2, ENSDART00000126177.3

Conserved Domains (3) summary

cd14660
Location:97 → 132

E2F_DD; coiled coil [structural motif]

pfam02319
Location:21 → 85

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

cl22411
Location:97 → 141

E2F_DD; Dimerization domain of E2F transcription factors