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eRF1 eukaryotic translation release factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40240, updated on 4-Apr-2024

Summary

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Official Symbol
eRF1provided by FlyBase
Official Full Name
eukaryotic translation release factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0036974
Locus tag
Dmel_CG5605
See related
AllianceGenome:FB:FBgn0036974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5605; deRF1; Dm0184; Dmel\CG5605; group J; Group J; l(3)00103; l(3)05637; l(3)77ABb; l(3)neo28
Summary
Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Involved in translational termination. Predicted to be part of translation release factor complex. Is expressed in adult head; adult heart; and organism. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
77B4-77B5; 3-47 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20348355..20353873)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20341455..20346973)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Serpin 77Bc Neighboring gene pseudo Neighboring gene Retinoblastoma binding protein 5 Neighboring gene uncharacterized protein Neighboring gene kin17 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons. Yang Q, et al. Nucleic Acids Res, 2019 Sep 26. PMID 31410471, Free PMC Article
  2. Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity. Ortega JA, et al. Neuron, 2020 Apr 8. PMID 32059759, Free PMC Article
  3. Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes. Dai Z, et al. PLoS Genet, 2020 Oct. PMID 33057338, Free PMC Article
  4. Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Chao AT, et al. Genetics, 2003 Oct. PMID 14573473, Free PMC Article
  5. Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine. Obata F, et al. Dev Cell, 2018 Mar 26. PMID 29587144

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sequence-specific mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation release factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation release factor activity, codon specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
involved_in translational termination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation release factor 1
Names
CG5605-PA
CG5605-PB
CG5605-PC
CG5605-PE
CG5605-PF
CG5605-PG
CG5605-PH
CG5605-PI
eRF1-PA
eRF1-PB
eRF1-PC
eRF1-PE
eRF1-PF
eRF1-PG
eRF1-PH
eRF1-PI
eukaryotic release factor 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20348355..20353873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275176.1 → NP_001262105.1  eukaryotic translation release factor 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262105.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFR9
    Conserved Domains (4) summary
    COG1503
    Location:11 → 414
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
    pfam03463
    Location:18 → 136
    eRF1_1; eRF1 domain 1
    pfam03464
    Location:145 → 277
    eRF1_2; eRF1 domain 2
    pfam03465
    Location:280 → 414
    eRF1_3; eRF1 domain 3

  2. NM_140953.3 → NP_649210.1  eukaryotic translation release factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649210.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V259, Q0E8C7, Q8T071, Q9VPH7
    UniProtKB/TrEMBL
    D1Z373
    Related
    FBpp0077835
    Conserved Domains (1) summary
    COG1503
    Location:11 → 420
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

  3. NM_168847.2 → NP_730519.1  eukaryotic translation release factor 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730519.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V259, Q0E8C7, Q8T071, Q9VPH7
    UniProtKB/TrEMBL
    D1Z373
    Related
    FBpp0077833
    Conserved Domains (1) summary
    COG1503
    Location:11 → 420
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

  4. NM_168845.2 → NP_730517.1  eukaryotic translation release factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730517.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V259, Q0E8C7, Q8T071, Q9VPH7
    UniProtKB/TrEMBL
    D1Z373
    Related
    FBpp0077832
    Conserved Domains (1) summary
    COG1503
    Location:11 → 420
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

  5. NM_168848.2 → NP_730520.1  eukaryotic translation release factor 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V259, Q0E8C7, Q8T071, Q9VPH7
    UniProtKB/TrEMBL
    D1Z373
    Related
    FBpp0077834
    Conserved Domains (1) summary
    COG1503
    Location:11 → 420
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

  6. NM_168846.2 → NP_730518.1  eukaryotic translation release factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730518.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V259, Q0E8C7, Q8T071, Q9VPH7
    UniProtKB/TrEMBL
    D1Z373
    Related
    FBpp0077831
    Conserved Domains (1) summary
    COG1503
    Location:11 → 420
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

  7. NM_001275175.1 → NP_001262104.1  eukaryotic translation release factor 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262104.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PD27
    Conserved Domains (1) summary
    COG1503
    Location:11 → 420
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

  8. NM_176369.3 → NP_788547.1  eukaryotic translation release factor 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V259, Q0E8C7, Q8T071, Q9VPH7
    UniProtKB/TrEMBL
    D1Z373
    Related
    FBpp0077836
    Conserved Domains (1) summary
    COG1503
    Location:11 → 420
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PD27 M9PD27
M9PFR9 M9PFR9
Q9VPH7.2 Q9VPH7

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