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Prp6 pre-mRNA processing factor 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40064, updated on 10-May-2024

Summary

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Official Symbol
Prp6provided by FlyBase
Official Full Name
pre-mRNA processing factor 6provided by FlyBase
Primary source
FLYBASE:FBgn0036828
Locus tag
Dmel_CG6841
See related
AllianceGenome:FB:FBgn0036828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD43276; CG6841; Dmel\CG6841
Summary
Predicted to enable RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; larval imaginal tissue; and trunk mesoderm. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Orthologous to human PRPF6 (pre-mRNA processing factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
75E4-75E5; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18905372..18908974)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18898472..18902001)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 1b Neighboring gene Cytochrome c oxidase subunit 6A-like 2 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy. Garcia EL, et al. RNA, 2016 Aug. PMID 27268418, Free PMC Article
  2. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
  3. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
  4. Identification of alternative splicing regulators by RNA interference in Drosophila. Park JW, et al. Proc Natl Acad Sci U S A, 2004 Nov 9. PMID 15492211, Free PMC Article
  5. Regulation of alternative splicing in Drosophila by 56 RNA binding proteins. Brooks AN, et al. Genome Res, 2015 Nov. PMID 26294686, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
involved_in spliceosomal tri-snRNP complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
pre-mRNA processing factor 6
Names
CG6841-PA
CG6841-PB
Prp6-PA
Prp6-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18905372..18908974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316442.1 → NP_001303371.1  pre-mRNA processing factor 6, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVU6
    Conserved Domains (5) summary
    smart00386
    Location:434 → 466
    HAT; HAT (Half-A-TPR) repeats
    COG0457
    Location:543 → 803
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:698 → 728
    TPR; TPR repeat [structural motif]
    pfam06424
    Location:22 → 173
    PRP1_N; PRP1 splicing factor, N-terminal
    pfam13428
    Location:665 → 708
    TPR_14; Tetratricopeptide repeat

  2. NM_140816.3 → NP_649073.1  pre-mRNA processing factor 6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649073.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVU6
    Related
    FBpp0074835
    Conserved Domains (5) summary
    smart00386
    Location:434 → 466
    HAT; HAT (Half-A-TPR) repeats
    COG0457
    Location:543 → 803
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:698 → 728
    TPR; TPR repeat [structural motif]
    pfam06424
    Location:22 → 173
    PRP1_N; PRP1 splicing factor, N-terminal
    pfam13428
    Location:665 → 708
    TPR_14; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SX58 Q8SX58
Q9VVU6 Q9VVU6

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