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CG7430 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39988, updated on 4-Apr-2024

Summary

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Official Symbol
CG7430provided by FlyBase
Primary source
FLYBASE:FBgn0036762
Locus tag
Dmel_CG7430
See related
AllianceGenome:FB:FBgn0036762
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG7430; E3
Summary
Predicted to enable dihydrolipoyl dehydrogenase activity and flavin adenine dinucleotide binding activity. Predicted to be involved in glycine catabolic process. Predicted to be part of glycine cleavage complex; mitochondrial pyruvate dehydrogenase complex; and oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic Malpighian tubule; embryonic/larval muscle system; extended germ band embryo; gut section; and spermatozoon. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
75A4-75A4; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17846916..17849601)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17840016..17842701)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45175 Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 19 Neighboring gene Tryptophanyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic basis of adaptation to copper pollution in Drosophila melanogaster. Everman ER, et al. Front Genet, 2023. PMID 37082199, Free PMC Article
  2. Proteomic profiling in Drosophila reveals potential Dube3a regulation of the actin cytoskeleton and neuronal homeostasis. Jensen L, et al. PLoS One, 2013. PMID 23626758, Free PMC Article
  3. Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. O'Keefe LV, et al. Hum Mol Genet, 2011 Feb 1. PMID 21075834, Free PMC Article
  4. Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development. Blagden SP, et al. Dev Biol, 2009 Oct 1. PMID 19631203
  5. SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis. Zhu JY, et al. Commun Biol, 2022 Sep 30. PMID 36180527, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dihydrolipoyl dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7430-PA
CG7430-PB
alpha-ketoglutarate dehydrogenase
alpha-ketoglutarate dehydrogenase E3 subunit
pyruvate dehydrogenase E3 subunit
NP_001262000.1
NP_649017.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17846916..17849601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140760.4 → NP_649017.1  uncharacterized protein Dmel_CG7430, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVL7
    Related
    FBpp0074906
    Conserved Domains (4) summary
    PRK06327
    Location:35 → 504
    PRK06327; dihydrolipoamide dehydrogenase; Validated
    pfam00070
    Location:211 → 290
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:385 → 491
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl21454
    Location:35 → 74
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001275071.1 → NP_001262000.1  uncharacterized protein Dmel_CG7430, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262000.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVL7
    Conserved Domains (4) summary
    PRK06327
    Location:35 → 504
    PRK06327; dihydrolipoamide dehydrogenase; Validated
    pfam00070
    Location:211 → 290
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:385 → 491
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl21454
    Location:35 → 74
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVL7 Q9VVL7

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