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U4-U6-60K U4-U6 small nuclear riboprotein factor 60K [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39955, updated on 10-May-2024

Summary

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Official Symbol
U4-U6-60Kprovided by FlyBase
Official Full Name
U4-U6 small nuclear riboprotein factor 60Kprovided by FlyBase
Primary source
FLYBASE:FBgn0036733
Locus tag
Dmel_CG6322
See related
AllianceGenome:FB:FBgn0036733
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6322; Dmel\CG6322; Prp4; U4/U6-60K
Summary
Enables U4 snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism and spermatozoon. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA processing factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
74D2-74D2; 3-45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17511855..17513912, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17504955..17507012, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene quijote Neighboring gene Organic anion transporting polypeptide 74D Neighboring gene elevated during infection Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Enhancer of decapping 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. Tycowski KT, et al. Mol Cell, 2009 Apr 10. PMID 19285445, Free PMC Article
  2. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
  3. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Liang D, et al. Mol Cell, 2017 Dec 7. PMID 29174924, Free PMC Article
  4. An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. Avet-Rochex A, et al. BMC Dev Biol, 2010 Jun 11. PMID 20540764, Free PMC Article
  5. Identification of Evolutionarily Conserved Nuclear Matrix Proteins and Their Prokaryotic Origins. Sureka R, et al. J Proteome Res, 2021 Jan 1. PMID 33289389

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables U4 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U4 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U6 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of small nuclear ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
U4-U6 small nuclear riboprotein factor 60K
Names
CG6322-PA
U4-U6-60K-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17511855..17513912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140733.3 → NP_648990.1  U4-U6 small nuclear riboprotein factor 60K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648990.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VVI0
    Related
    FBpp0074971
    Conserved Domains (4) summary
    smart00500
    Location:132 → 166
    SFM; Splicing Factor Motif, present in Prp18 and Pr04
    COG2319
    Location:286 → 553
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:286 → 550
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:357 → 393
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVI0 Q9VVI0

Gene LinkOut

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