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VWF von Willebrand factor [ Canis lupus familiaris (dog) ]

Gene ID: 399544, updated on 5-Mar-2024

Summary

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Official Symbol
VWFprovided by VGNC
Official Full Name
von Willebrand factorprovided by VGNC
Primary source
VGNC:VGNC:48329
See related
Ensembl:ENSCAFG00845029798
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
F8VWF
Orthologs
human mouse all
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Genomic context

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See VWF in Genome Data Viewer
Location:
chromosome: 27
Exon count:
54
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (39191850..39329540)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (7641828..7779174, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (7119622..7257688, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (39062625..39200071)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (39104190..39241989)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866432 Neighboring gene uncharacterized LOC102157333 Neighboring gene CD9 molecule Neighboring gene anoctamin 2 Neighboring gene uncharacterized LOC111092786 Neighboring gene neurotrophin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers. Vos-Loohuis M, et al. Anim Genet, 2017 Aug. PMID 28696025
  2. Mutation causing von Willebrand's disease in Scottish Terriers. Venta PJ, et al. J Vet Intern Med, 2000 Jan-Feb. PMID 10668811
  3. [Expressions of CD31 and vWF in arachnoid villus endothelium cell from experimental animal with Hydrocephalus]. Wang ER, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2007 Jun. PMID 17593818
  4. Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells. Haberichter SL, et al. Blood, 2005 Jan 1. PMID 15331450, Free PMC Article
  5. von Willebrand factor storage and multimerization: 2 independent intracellular processes. Haberichter SL, et al. Blood, 2000 Sep 1. PMID 10961880

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. only the c.1657G variant was found in the homozygous state exclusively in Von Willebrand disease affected dogs, and this variant is the strongest candidate to be the cause of VWD type 2 in the German Wirehaired Pointer and German Shorthaired Pointer breeds
    Title: A novel VWF variant associated with type 2 von Willebrand disease in German Wirehaired Pointers and German Shorthaired Pointers.
  2. the CD-31 and vonWillebrand factor (vWF) expressions and the cell morphological alterations ofarachnoid villus endothelium in different stages of animal hydrocephalus
    Title: [Expressions of CD31 and vWF in arachnoid villus endothelium cell from experimental animal with Hydrocephalus].
  3. Expression of mutant VWF proteins confirmed that VWF multimerization is not necessary for Weibel-Palade body creation
    Title: Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
von Willebrand factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002932.1 → NP_001002932.1  von Willebrand factor precursor

    See identical proteins and their annotated locations for NP_001002932.1

    Status: PROVISIONAL

    Source sequence(s)
    U66246
    UniProtKB/TrEMBL
    A0A219Y8W3
    Related
    ENSCAFP00845041932.1, ENSCAFT00845053377.1
    Conserved Domains (13) summary
    smart00041
    Location:2727 → 2808
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:2261 → 2321
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:377 → 540
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:1277 → 1449
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:1053 → 1127
    C8; This domain contains 8 conserved cysteine residues
    cd01450
    Location:1497 → 1645
    vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam00092
    Location:1691 → 1860
    VWA; von Willebrand factor type A domain
    pfam00093
    Location:2431 → 2494
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:35 → 179
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:652 → 707
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2135 → 2199
    C8; C8 domain
    pfam16164
    Location:1198 → 1276
    VWA_N2; VWA N-terminal
    cl17735
    Location:2582 → 2644
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    39191850..39329540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437724.1 → XP_038293652.1  von Willebrand factor isoform X1

    UniProtKB/TrEMBL
    A0A8I3SCK0
    Conserved Domains (13) summary
    smart00041
    Location:2731 → 2812
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:2265 → 2325
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:381 → 544
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:1281 → 1453
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:1057 → 1131
    C8; This domain contains 8 conserved cysteine residues
    cd01450
    Location:1501 → 1649
    vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam00093
    Location:2435 → 2498
    VWC; von Willebrand factor type C domain
    cl17735
    Location:2586 → 2648
    VWC; von Willebrand factor type C domain
    pfam00092
    Location:1695 → 1864
    VWA; von Willebrand factor type A domain
    pfam00094
    Location:39 → 183
    VWD; von Willebrand factor type D domain
    pfam08742
    Location:2142 → 2203
    C8; C8 domain
    pfam16164
    Location:1202 → 1280
    VWA_N2; VWA N-terminal
    cd19941
    Location:656 → 711
    TIL; trypsin inhibitor-like cysteine rich domain

RNA

  1. XR_005302758.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    39062625..39200071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    39104190..39241989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    7119622..7257688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    7641828..7779174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28295.2 GenPept UniProtKB/Swiss-Prot:Q28295

Gene LinkOut

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