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eIF3e eukaryotic translation initiation factor 3 subunit e [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39877, updated on 4-Apr-2024

Summary

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Official Symbol
eIF3eprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 3 subunit eprovided by FlyBase
Primary source
FLYBASE:FBgn0025582
Locus tag
Dmel_CG9677
See related
AllianceGenome:FB:FBgn0025582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA.GM01233; BcDNA:GM01233; CG9677; DINT6; Dmel\CG9677; eIF-3p48/INT-6; eIF3-p48/INT6; eIF3-S6; Int6; l(3)10547; l(3)j9E8
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Located in intracellular membrane-bounded organelle. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; and extended germ band embryo. Orthologous to human EIF3E (eukaryotic translation initiation factor 3 subunit E). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See eIF3e in Genome Data Viewer
Location:
73C4-73C4; 3-44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16785242..16786941, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16778342..16780041, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Neurotactin Neighboring gene mutagen-sensitive 302 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nudC Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure. Renda F, et al. PLoS Genet, 2017 May. PMID 28505193, Free PMC Article
  2. Characterization of the Drosophila ortholog of mouse eIF-3p48/INT-6. Miyazaki S, et al. Gene, 1999 Jun 11. PMID 10375641
  3. Characterization of DnudC, the Drosophila homolog of an Aspergillus gene that functions in nuclear motility. Cunniff J, et al. Mech Dev, 1997 Aug. PMID 9376324
  4. The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. Rencus-Lazar S, et al. PLoS One, 2008 May 21. PMID 18493598, Free PMC Article
  5. The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. Parry TJ, et al. Genes Dev, 2010 Sep 15. PMID 20801935, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of Int6 results in short mitotic spindles and deformed centromeres and kinetochores. Int6-mediated ubiquitination is required to control the activity of Klp67A.
    Title: The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.
  2. Int6 and the COP9 signalosome play opposing roles in regulation of cullin neddylation
    Title: The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit e
Names
CG9677-PA
Int6
Int6 homologue
eIF3e-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16785242..16786941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058037.5 → NP_477385.1  eukaryotic translation initiation factor 3 subunit e [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477385.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77410, Q9VVA2
    UniProtKB/TrEMBL
    Q8MR88
    Related
    FBpp0075104
    Conserved Domains (1) summary
    cd21378
    Location:3 → 418
    eIF3E; eukaryotic translation initiation factor 3 subunit E
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77410.1 O77410

Gene LinkOut

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