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Prosbeta6 Proteasome beta6 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39855, updated on 5-May-2024

Summary

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Official Symbol
Prosbeta6provided by FlyBase
Official Full Name
Proteasome beta6 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0002284
Locus tag
Dmel_CG4097
See related
AllianceGenome:FB:FBgn0002284
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
b6; beta-6; Beta-6; beta6; beta6_dm; CG4097; Dmel\CG4097; DTS-5; DTS5; l(3)73Ai; l(3)DTS-5; l(3)DTS5; pros26; Pros26; Pros26-DTS; pros26B; pros26beta6; prosbeta6; PSB1_DROME; PSMB1
Summary
Predicted to enable peptidase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including adult heart; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and germ layer. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
73B1-73B1; 3-44 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16609400..16610418, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16602500..16603518, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Apollo Neighboring gene pseudo Neighboring gene Artemis Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45865 Neighboring gene Suppressor of ref(2)P sterility Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteasome inhibition induces developmentally deregulated programs of apoptotic and autophagic cell death during Drosophila melanogaster oogenesis. Velentzas PD, et al. Cell Biol Int, 2011 Jan. PMID 20819072
  2. Degradation of functional triose phosphate isomerase protein underlies sugarkill pathology. Seigle JL, et al. Genetics, 2008 Jun. PMID 18458110, Free PMC Article
  3. Targeted expression of dominant negative proteasome mutants in Drosophila melanogaster. Belote JM, et al. Genesis, 2002 Sep-Oct. PMID 12324954
  4. The Binding of CSL Proteins to Either Co-Activators or Co-Repressors Protects from Proteasomal Degradation Induced by MAPK-Dependent Phosphorylation. Fechner J, et al. Int J Mol Sci, 2022 Oct 15. PMID 36293193, Free PMC Article
  5. Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth. Balakrishnan M, et al. Cell Rep, 2020 Jul 21. PMID 32697999, Free PMC Article

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. assembly of the Drosophila 26 S proteasome accompanied by extensive subunit rearrangements
    Title: Assembly of the Drosophila 26 S proteasome is accompanied by extensive subunit rearrangements.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables peptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome beta6 subunit
Names
20S proteasome
CG4097-PA
Prosbeta6-PA
beta6
beta6 proteosome subunit
proteasome 26kD subunit
proteasome beta6
proteasome subunit 20S

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16609400..16610418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079391.3 → NP_524115.1  proteasome beta6 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40304, Q9VV84
    Related
    FBpp0075119
    Conserved Domains (2) summary
    COG0638
    Location:24 → 225
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03757
    Location:22 → 235
    proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77288 O77288
P40304.2 P40304

Gene LinkOut

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