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PolD1 DNA polymerase delta subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39746, updated on 27-Mar-2024

Summary

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Official Symbol
PolD1provided by FlyBase
Official Full Name
DNA polymerase delta subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0263600
Locus tag
Dmel_CG5949
See related
AllianceGenome:FB:FBgn0263600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5949; CAA61369; CG5949; Dm Poldelta; Dmel\CG5949; DNA pol delta; DNA Pol Delta; dnapol delta; DNApol-delta; l(3)72Ac; Pol delta125; polD; Poldelta; Poldelta 125KDa; Poldelta125KDa
Summary
Enables 3'-5'-exodeoxyribonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA replication proofreading. Located in nucleoplasm. Part of delta DNA polymerase complex. Is expressed in several structures, including ectoderm; embryonic Malpighian tubule; embryonic/larval midgut; extended germ band embryo; and presumptive embryonic/larval system. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PolD1 in Genome Data Viewer
Location:
72C1-72C1; 3-43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15984322..15987815, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15977422..15980915, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene brahma Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45446 Neighboring gene ADP ribosylation factor-like 1 Neighboring gene Huntingtin-interacting protein 14 Neighboring gene herzog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and sequence determination of the cDNA encoding DNA polymerase delta from Drosophila melanogaster. Chiang CS, et al. Gene, 1995 Dec 12. PMID 8543168
  2. DNA polymerase delta from embryos of Drosophila melanogaster. Chiang CS, et al. Proc Natl Acad Sci U S A, 1993 Oct 1. PMID 8415662, Free PMC Article
  3. Drosophila DNA polymerase delta. Purification and characterization. Aoyagi N, et al. J Biol Chem, 1994 Feb 25. PMID 7907087
  4. Delta-type DNA polymerase characterized from Drosophila melanogaster embryos. Peck VM, et al. Nucleic Acids Res, 1992 Nov 11. PMID 1360647, Free PMC Article
  5. Characterization of a second proliferating cell nuclear antigen (PCNA2) from Drosophila melanogaster. Ruike T, et al. FEBS J, 2006 Nov. PMID 17087725

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription
    Title: Novel TRF1/BRF target genes revealed by genome-wide analysis of Drosophila Pol III transcription.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5'-DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication proofreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication proofreading IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair, gap-filling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair, DNA gap filling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of delta DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of delta DNA polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA polymerase delta subunit 1
Names
CG5949-PA
DNA polymerase delta
DNA polymerase-delta
DNA-polymerase-delta
DNApol-delta
PolD1-PA
lethal (3) 72Ac
NP_524099.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15984322..15987815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079375.3 → NP_524099.2  DNA polymerase delta subunit 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524099.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54358, Q9VUW8
    Related
    FBpp0075277
    Conserved Domains (4) summary
    cd05777
    Location:288 → 517
    DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
    cd05533
    Location:564 → 960
    POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
    PTZ00166
    Location:48 → 1092
    PTZ00166; DNA polymerase delta catalytic subunit; Provisional
    pfam14260
    Location:997 → 1070
    zf-C4pol; C4-type zinc-finger of DNA polymerase delta
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54358.2 P54358

Gene LinkOut

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