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mrn marionette [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39688, updated on 27-Mar-2024

Summary

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Official Symbol
mrnprovided by FlyBase
Official Full Name
marionetteprovided by FlyBase
Primary source
FLYBASE:FBgn0261109
Locus tag
Dmel_CG7764
See related
AllianceGenome:FB:FBgn0261109
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
154538_at; anon-WO0118547.648; CG7764; Dmel\CG7764; Dmp52; l(3)E35; ms(3)nc16; nc16; p52; Tfb2; TFB2
Summary
Enables ATPase activator activity. Involved in nucleotide-excision repair; response to UV-B; and transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval nervous system; and epithelium. Orthologous to human GTF2H4 (general transcription factor IIH subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See mrn in Genome Data Viewer
Location:
71E1-71E1; 3-43 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15578769..15580537, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15571869..15573637, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene drop out Neighboring gene UFM1 specific peptidase 2 Neighboring gene uncharacterized protein Neighboring gene aaRS-interacting multifunctional protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of recombinant trp by thapsigargin in Sf9 insect cells. Vaca L, et al. Am J Physiol, 1994 Nov. PMID 7977711
  2. The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. Villicaña C, et al. J Cell Sci, 2013 Jun 1. PMID 23549790
  3. Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks. Rong YS. Chromosoma, 2008 Jun. PMID 18193446
  4. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Fregoso M, et al. Mol Cell Biol, 2007 May. PMID 17339330, Free PMC Article
  5. Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH. Herrera-Cruz M, et al. J Biol Chem, 2012 Sep 28. PMID 22865882, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the enhanced apoptosis caused by the simultaneous depletion of Dp53 and Dmp52 is absolutely JNK-dependent.
    Title: The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II promoter clearance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to UV-B IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription open complex formation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH core complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIIH core complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
marionette
Names
CG7764-PA
Tfb2
marionnette
mrn-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15578769..15580537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140523.4 → NP_648780.1  marionette [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUR1
    Related
    FBpp0075348
    Conserved Domains (1) summary
    pfam03849
    Location:39 → 403
    Tfb2; Transcription factor Tfb2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TQ5 Q95TQ5
Q9VUR1 Q9VUR1

Gene LinkOut

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