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Ugt1a9 UDP glucuronosyltransferase family 1 member A9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 396552, updated on 29-Feb-2024

Summary

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Official Symbol
Ugt1a9provided by RGD
Official Full Name
UDP glucuronosyltransferase family 1 member A9provided by RGD
Primary source
RGD:1549771
See related
AllianceGenome:RGD:1549771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ugt1a10; Ugt1a11
Summary
Predicted to enable several functions, including glucuronosyltransferase activity; protein dimerization activity; and retinoic acid binding activity. Predicted to be involved in several processes, including cellular glucuronidation; negative regulation of glucuronosyltransferase activity; and negative regulation of small molecule metabolic process. Predicted to be located in endoplasmic reticulum. Orthologous to human UGT1A9 (UDP glucuronosyltransferase family 1 member A9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1919.8), Kidney (RPKM 838.1) and 2 other tissues See more
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Genomic context

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See Ugt1a9 in Genome Data Viewer
Location:
9q35
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96144786..96256264)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88696981..88808465)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95161157..95302822)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, delta Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A9, pseudogene Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene peptidylprolyl isomerase D, pseudogene 21 Neighboring gene transient receptor potential cation channel, subfamily M, member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Strassburg CP, et al. Cancer Res, 1997 Jul 15. PMID 9230212
  2. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. Wooster R, et al. Biochem J, 1991 Sep 1. PMID 1910331, Free PMC Article
  3. Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Girard H, et al. Pharmacogenet Genomics, 2007 Dec. PMID 18004212
  4. Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Joseph TB, et al. Mol Pharm, 2007 Nov-Dec. PMID 18052087, Free PMC Article
  5. Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Bellemare J, et al. Drug Metab Dispos, 2010 Oct. PMID 20610558

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in flavone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in flavonoid glucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic glucuronidation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP glycosyltransferase 1 family, polypeptide A10
Names
UDP glucuronosyltransferase 1 family, polypeptide A9
UDP glycosyltransferase 1 family polypeptide A10
UDP glycosyltransferase 1 family polypeptide A11
NP_958828.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201425.2 → NP_958828.1  UDP glycosyltransferase 1 family, polypeptide A10 precursor

    See identical proteins and their annotated locations for NP_958828.1

    Status: VALIDATED

    Source sequence(s)
    AC120922, AY435129
    UniProtKB/TrEMBL
    Q6T5F3
    Conserved Domains (2) summary
    PHA03392
    Location:237 → 504
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:26 → 521
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    96144786..96256264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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