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Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 396527, updated on 5-Mar-2024

Summary

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Official Symbol
Ugt1a2provided by RGD
Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A2provided by RGD
Primary source
RGD:1549741
See related
Ensembl:ENSRNOG00000018740 AllianceGenome:RGD:1549741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ugt1; Udpgt; UDPGT 1-2
Summary
Predicted to enable several functions, including glucuronosyltransferase activity; protein dimerization activity; and retinoic acid binding activity. Involved in animal organ regeneration; liver development; and response to organic cyclic compound. Predicted to be located in endoplasmic reticulum. Orthologous to human UGT1A3 (UDP glucuronosyltransferase family 1 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 2015.6), Kidney (RPKM 841.4) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q35
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96239019..96256264)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88791216..88808465)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95285592..95302822)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene uncharacterized LOC108351970 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A4, pseudogene Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene Holliday junction recognition protein Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional enhancement of UDP-glucuronosyltransferase form 1A2 (UGT1A2) by nuclear factor I-A (NFI-A) in rat hepatocytes. Emi Y, et al. J Biochem, 2005 Sep. PMID 16169882
  2. Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats. Tian H, et al. Pharm Res, 2005 Dec. PMID 16222444
  3. Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver. Kishi M, et al. Biochem Biophys Res Commun, 2008 Dec 19. PMID 18938141
  4. Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation. Vansell NR, et al. Drug Metab Dispos, 2002 Mar. PMID 11854140
  5. Isolation and sequencing of rat liver bilirubin UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript. Sato H, et al. Biochem Biophys Res Commun, 1990 May 31. PMID 2112380

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables retinoic acid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in bile acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular glucuronidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular glucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in flavonoid glucuronidation ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in vitamin D3 metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic glucuronidation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase 1-2
Names
B2
UDP glucuronosyltransferase 1A2
UDP glycosyltransferase 1 family polypeptide A2
UGT1*0
UGT1-02
UGT1.2
bilirubin specific
bilirubin-specific UDPGT
NP_958826.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201423.2 → NP_958826.1  UDP-glucuronosyltransferase 1-2 precursor

    See identical proteins and their annotated locations for NP_958826.1

    Status: VALIDATED

    Source sequence(s)
    AC120922, AY435130
    UniProtKB/Swiss-Prot
    P20720, Q64636
    UniProtKB/TrEMBL
    F7EP24, Q6T5F2
    Related
    ENSRNOP00000062958.1, ENSRNOT00000063853.5
    Conserved Domains (2) summary
    PHA03392
    Location:261 → 507
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:28 → 524
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    96239019..96256264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20720.2 GenPept UniProtKB/Swiss-Prot:P20720

Gene LinkOut

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