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FGFR1 fibroblast growth factor receptor 1 [ Gallus gallus (chicken) ]

Gene ID: 396516, updated on 5-Mar-2024

Summary

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Symbol
FGFR1provided by CGNC
Full Name
fibroblast growth factor receptor 1provided by CGNC
Primary source
CGNC:49847
See related
Ensembl:ENSGALG00010017332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CEK1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 22 NC_052553.1 (2504806..2524443, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 22 NC_052594.1 (2552138..2571772, complement)

Chromosome 22 - NC_052553.1Genomic Context describing neighboring genes Neighboring gene Wolf-Hirschhorn syndrome candidate 1-like 1 Neighboring gene phospholipid phosphatase 5 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene transforming acidic coiled-coil containing protein 1 Neighboring gene uncharacterized LOC121107413 Neighboring gene pleckstrin homology domain containing A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bimodal, reciprocal regulation of fibroblast growth factor receptor 1 promoter activity by BTEB1/KLF9 during myogenesis. Mitchell DL, et al. Mol Biol Cell, 2010 Aug 1. PMID 20554758, Free PMC Article
  2. Purification and complementary DNA cloning of a receptor for basic fibroblast growth factor. Lee PL, et al. Science, 1989 Jul 7. PMID 2544996
  3. Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library. Pasquale EB, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2473471, Free PMC Article
  4. Effect of anti-fibroblast growth factor receptor 1 antibodies on phosphorus metabolism in laying hens and their progeny chicks. Ren Z, et al. Poult Sci, 2019 Nov 1. PMID 31237331
  5. AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity. Mitchell DL, et al. Exp Cell Res, 2010 Jan 15. PMID 19699737

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anti-FGFR1 peptide antibodies decreased egg production of hens and growth performance of their progeny chicks probably by activating FGF-23 signaling and stimulating FGF-23 production.
    Title: Effect of anti-fibroblast growth factor receptor 1 antibodies on phosphorus metabolism in laying hens and their progeny chicks.
  2. FGFR1 promoter activity in skeletal muscle cells is repressed by E2F4.
    Title: Repression of fibroblast growth factor receptor 1 gene expression by E2F4 in skeletal muscle cells.
  3. BTEB1 activated the FGFR1 promoter via interaction with the Sp1-like binding site located at -59 bp within the FGFR1 promoter.
    Title: Bimodal, reciprocal regulation of fibroblast growth factor receptor 1 promoter activity by BTEB1/KLF9 during myogenesis.
  4. results indicate that AP-2 alpha is a transcriptional repressor of FGFR1 gene expression during skeletal myogenesis
    Title: AP-2 alpha suppresses skeletal myoblast proliferation and represses fibroblast growth factor receptor 1 promoter activity.
  5. a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development
    Title: Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.
  6. Data suggest that the FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin.
    Title: FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470).
  7. FGF receptors are expressed only in epithelia of the embryonic digestive tract.
    Title: Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 1
Names
FGFR-1
bFGF-R-1
basic fibroblast growth factor receptor 1
cek1 protein
fibroblast growth factor receptor 1-IIIc
tyrosine kinase receptor CEK1
NP_990841.2
XP_015152847.2
XP_015152849.2
XP_015152852.2
XP_024998538.1
XP_040507404.1
XP_040507405.1
XP_046759308.1
XP_046787544.1
XP_046787545.1
XP_046787546.1
XP_046787548.1
XP_046787549.1
XP_046787550.1
XP_046787551.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205510.2 → NP_990841.2  fibroblast growth factor receptor 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000332
    UniProtKB/TrEMBL
    A0A8V0Z0L3
    Conserved Domains (6) summary
    cd05098
    Location:460 → 761
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253 → 256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 117
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151 → 245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253 → 357
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2504806..2524443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025142770.3 → XP_024998538.1  fibroblast growth factor receptor 1 isoform X6

    Conserved Domains (3) summary
    cd05857
    Location:73 → 157
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:180 → 269
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:372 → 673
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

  2. XM_015297366.4 → XP_015152852.2  fibroblast growth factor receptor 1 isoform X5

    Conserved Domains (3) summary
    cd05857
    Location:73 → 157
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05098
    Location:376 → 677
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    cl11960
    Location:180 → 266
    Ig; Immunoglobulin domain

  3. XM_040651470.2 → XP_040507404.1  fibroblast growth factor receptor 1 isoform X3

    UniProtKB/Swiss-Prot
    P21804
    Conserved Domains (6) summary
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253 → 256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 117
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151 → 245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253 → 357
    Ig; Immunoglobulin domain

  4. XM_015297361.4 → XP_015152847.2  fibroblast growth factor receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7L6
    Related
    ENSGALP00010024445.1, ENSGALT00010041806.1
    Conserved Domains (4) summary
    cd04973
    Location:39 → 117
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161 → 245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    cl11960
    Location:268 → 354
    Ig; Immunoglobulin domain

  5. XM_015297363.4 → XP_015152849.2  fibroblast growth factor receptor 1 isoform X1

    Conserved Domains (4) summary
    cd04973
    Location:39 → 117
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161 → 245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05098
    Location:464 → 765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    cl11960
    Location:268 → 354
    Ig; Immunoglobulin domain

  6. XM_040651471.2 → XP_040507405.1  fibroblast growth factor receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z0L3
    Related
    ENSGALP00010024448.1, ENSGALT00010041811.1
    Conserved Domains (6) summary
    cd05098
    Location:460 → 761
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253 → 256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 117
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151 → 245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253 → 357
    Ig; Immunoglobulin domain

  7. XM_046903352.1 → XP_046759308.1  fibroblast growth factor receptor 1 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052594.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2552138..2571772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931595.1 → XP_046787551.1  fibroblast growth factor receptor 1 isoform X6

  2. XM_046931594.1 → XP_046787550.1  fibroblast growth factor receptor 1 isoform X5

  3. XM_046931590.1 → XP_046787546.1  fibroblast growth factor receptor 1 isoform X3

    UniProtKB/Swiss-Prot
    P21804

  4. XM_046931589.1 → XP_046787545.1  fibroblast growth factor receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z7L6

  5. XM_046931588.1 → XP_046787544.1  fibroblast growth factor receptor 1 isoform X1

  6. XM_046931593.1 → XP_046787549.1  fibroblast growth factor receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z0L3

  7. XM_046931592.1 → XP_046787548.1  fibroblast growth factor receptor 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21804.1 GenPept UniProtKB/Swiss-Prot:P21804

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