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FGFR3 fibroblast growth factor receptor 3 [ Gallus gallus (chicken) ]

Gene ID: 396515, updated on 3-Apr-2024

Summary

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Symbol
FGFR3provided by CGNC
Full Name
fibroblast growth factor receptor 3provided by CGNC
Primary source
CGNC:49846
See related
Ensembl:ENSGALG00010016940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CEK2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
20
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (82918126..82970476, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (82896459..82948926, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 23 Neighboring gene Wolf-Hirschhorn syndrome candidate 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene ADP/ATP translocase 4-like Neighboring gene uncharacterized LOC101749105 Neighboring gene uncharacterized LOC121110683

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles of FGFR3 during morphogenesis of Meckel's cartilage and mandibular bones. Havens BA, et al. Dev Biol, 2008 Apr 15. PMID 18339367, Free PMC Article
  2. FGF signaling in mandibular skeletogenesis. Mina M, et al. Orthod Craniofac Res, 2007 May. PMID 17552942
  3. A distinctive family of embryonic protein-tyrosine kinase receptors. Pasquale EB. Proc Natl Acad Sci U S A, 1990 Aug. PMID 2165604, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 3
Names
FGFR-3
fibroblast growth factor receptor 3-IIIc
tyrosine kinase (cek2)
tyrosine kinase receptor CEK2
NP_990840.2
XP_015141362.1
XP_015141363.1
XP_015141364.1
XP_015141365.1
XP_015141367.1
XP_015141368.1
XP_015141369.1
XP_015141370.1
XP_046771553.1
XP_046771554.1
XP_046771555.1
XP_046771556.1
XP_046771557.1
XP_046771558.1
XP_046771559.1
XP_046771560.1
XP_046771561.1
XP_046795898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205509.3 → NP_990840.2  fibroblast growth factor receptor 3

    See identical proteins and their annotated locations for NP_990840.2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P18460
    UniProtKB/TrEMBL
    A0A8V0YZ02
    Related
    ENSGALP00010023873.1, ENSGALT00010040908.1
    Conserved Domains (7) summary
    cd05857
    Location:176 → 260
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:283 → 372
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:474 → 807
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:186 → 260
    IG; Immunoglobulin
    smart00410
    Location:275 → 371
    IG_like; Immunoglobulin like
    pfam07714
    Location:487 → 763
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    82918126..82970476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015285877.4 → XP_015141363.1  fibroblast growth factor receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    P18460
    Conserved Domains (7) summary
    cd04974
    Location:283 → 370
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:176 → 260
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:477 → 810
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:75 → 144
    IG; Immunoglobulin
    smart00410
    Location:275 → 370
    IG_like; Immunoglobulin like
    pfam07714
    Location:490 → 766
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_015285876.4 → XP_015141362.1  fibroblast growth factor receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    P18460
    Conserved Domains (7) summary
    cd04974
    Location:283 → 370
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:176 → 260
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:477 → 810
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:75 → 144
    IG; Immunoglobulin
    smart00410
    Location:275 → 370
    IG_like; Immunoglobulin like
    pfam07714
    Location:490 → 766
    Pkinase_Tyr; Protein tyrosine kinase

  3. XM_015285883.4 → XP_015141369.1  fibroblast growth factor receptor 3 isoform X6

    UniProtKB/Swiss-Prot
    P18460
    Conserved Domains (7) summary
    cd04974
    Location:265 → 352
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:158 → 242
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:459 → 792
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:75 → 144
    IG; Immunoglobulin
    smart00410
    Location:257 → 352
    IG_like; Immunoglobulin like
    pfam07714
    Location:472 → 748
    Pkinase_Tyr; Protein tyrosine kinase

  4. XM_015285882.4 → XP_015141368.1  fibroblast growth factor receptor 3 isoform X5

    UniProtKB/Swiss-Prot
    P18460
    Conserved Domains (7) summary
    cd05857
    Location:176 → 260
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:283 → 372
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:473 → 806
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:186 → 260
    IG; Immunoglobulin
    smart00410
    Location:275 → 371
    IG_like; Immunoglobulin like
    pfam07714
    Location:486 → 762
    Pkinase_Tyr; Protein tyrosine kinase

  5. XM_015285881.4 → XP_015141367.1  fibroblast growth factor receptor 3 isoform X4

    UniProtKB/Swiss-Prot
    P18460
    Conserved Domains (7) summary
    cd05857
    Location:176 → 260
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:283 → 372
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05100
    Location:475 → 808
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:75 → 144
    IG; Immunoglobulin
    smart00410
    Location:275 → 371
    IG_like; Immunoglobulin like
    pfam07714
    Location:488 → 764
    Pkinase_Tyr; Protein tyrosine kinase

  6. XM_015285879.4 → XP_015141365.1  fibroblast growth factor receptor 3 isoform X3

    UniProtKB/Swiss-Prot
    P18460
    Conserved Domains (7) summary
    cd04974
    Location:283 → 370
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:176 → 260
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:475 → 808
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:75 → 144
    IG; Immunoglobulin
    smart00410
    Location:275 → 370
    IG_like; Immunoglobulin like
    pfam07714
    Location:488 → 764
    Pkinase_Tyr; Protein tyrosine kinase

  7. XM_015285878.4 → XP_015141364.1  fibroblast growth factor receptor 3 isoform X2

    UniProtKB/Swiss-Prot
    P18460
    UniProtKB/TrEMBL
    A0A8V0YYZ7
    Related
    ENSGALP00010023868.1, ENSGALT00010040904.1
    Conserved Domains (7) summary
    cd04974
    Location:283 → 370
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:176 → 260
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:476 → 809
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:74 → 134
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:75 → 144
    IG; Immunoglobulin
    smart00410
    Location:275 → 370
    IG_like; Immunoglobulin like
    pfam07714
    Location:489 → 765
    Pkinase_Tyr; Protein tyrosine kinase

  8. XM_046939942.1 → XP_046795898.1  fibroblast growth factor receptor 3 isoform X1

  9. XM_015285884.4 → XP_015141370.1  fibroblast growth factor receptor 3 isoform X7

    UniProtKB/Swiss-Prot
    P18460
    Conserved Domains (7) summary
    cd04974
    Location:232 → 319
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:125 → 209
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05100
    Location:426 → 759
    PTKc_FGFR3; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3
    smart00408
    Location:23 → 83
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:24 → 93
    IG; Immunoglobulin
    smart00410
    Location:224 → 319
    IG_like; Immunoglobulin like
    pfam07714
    Location:439 → 715
    Pkinase_Tyr; Protein tyrosine kinase

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    82896459..82948926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915599.1 → XP_046771555.1  fibroblast growth factor receptor 3 isoform X1

  2. XM_046915598.1 → XP_046771554.1  fibroblast growth factor receptor 3 isoform X1

  3. XM_046915604.1 → XP_046771560.1  fibroblast growth factor receptor 3 isoform X6

  4. XM_046915603.1 → XP_046771559.1  fibroblast growth factor receptor 3 isoform X5

  5. XM_046915602.1 → XP_046771558.1  fibroblast growth factor receptor 3 isoform X4

  6. XM_046915601.1 → XP_046771557.1  fibroblast growth factor receptor 3 isoform X3

  7. XM_046915600.1 → XP_046771556.1  fibroblast growth factor receptor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V0YYZ7

  8. XM_046915597.1 → XP_046771553.1  fibroblast growth factor receptor 3 isoform X1

  9. XM_046915605.1 → XP_046771561.1  fibroblast growth factor receptor 3 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18460.1 GenPept UniProtKB/Swiss-Prot:P18460

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