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EPHB2 EPH receptor B2 [ Gallus gallus (chicken) ]

Gene ID: 396513, updated on 11-Apr-2024

Summary

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Symbol
EPHB2provided by CGNC
Full Name
EPH receptor B2provided by CGNC
Primary source
CGNC:3515
See related
Ensembl:ENSGALG00010016847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 21
Exon count:
16
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 21 NC_052552.1 (5938662..6036745, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 21 NC_052593.1 (5973052..6071127, complement)

Chromosome 21 - NC_052552.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC419500 Neighboring gene uncharacterized LOC101751948 Neighboring gene uncharacterized LOC121107396 Neighboring gene complement C1q B chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EphB2 regulates axonal growth at the midline in the developing auditory brainstem. Cramer KS, et al. Dev Biol, 2006 Jul 1. PMID 16626680
  2. Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family. Pasquale EB. Cell Regul, 1991 Jul. PMID 1664238, Free PMC Article
  3. Differential roles for EphA and EphB signaling in segregation and patterning of central vestibulocochlear nerve projections. Allen-Sharpley MR, et al. PLoS One, 2013. PMID 24130906, Free PMC Article
  4. EphB2/B3 gene expression is down-regulated during early embryogenesis in the cadmium-induced omphalocele chick model. Doi T, et al. J Pediatr Surg, 2012 May. PMID 22595573
  5. Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition. Harris ML, et al. Development, 2008 Dec. PMID 19004859

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance.
    Title: The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance.
  2. Misexpression of EphA4 and EphB2 in VIIIth nerve axons resulted in a significant shift of dorsoventral spacing between the axon tracts, suggesting a cell-autonomous role for the partitioning of projection areas along this axis.
    Title: Differential roles for EphA and EphB signaling in segregation and patterning of central vestibulocochlear nerve projections.
  3. Downregulation of EphB2/B3 during the narrow window of early embryogenesis may interfere with normal somitogenesis, preventing migration of embryonic body wall ventrally and thus causing omphalocele.
    Title: EphB2/B3 gene expression is down-regulated during early embryogenesis in the cadmium-induced omphalocele chick model.
  4. the requirement for EDNRB2 and EphB2 expression by melanoblasts is to support their migration by helping them to overcome repulsive or non-permissive cues in the dorsolateral environment
    Title: Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition.
  5. avian cranial neural crest cells express ephrin-B2 and migrate along pathways bordered by non-neural crest cells expressing EphB2
    Title: Divergent roles for Eph and ephrin in avian cranial neural crest.
  6. EphB2 low levels permit axon growth and subsequently high levels prohibit growth after axons have crossed the midline
    Title: EphB2 regulates axonal growth at the midline in the developing auditory brainstem.
  7. The results demonstrate that local inhibitory interactions within inter-ganglionic regions, mediated by Eph/ephrins, and adhesive cell-cell contacts at ganglia sites, mediated by N-cadherin, coordinate to sculpt discrete sympathetic ganglia.
    Title: Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system projection neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ephrin type-B receptor 2
Names
EK5
EPH-like kinase 5
cEK5
chicken embryo kinase 5
embryo kinase 5 protein CEK5
NP_996834.1
XP_015152322.1
XP_015152323.1
XP_015152324.1
XP_046787123.1
XP_046787124.1
XP_046787125.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206951.4 → NP_996834.1  ephrin type-B receptor 2 precursor

    See identical proteins and their annotated locations for NP_996834.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000329
    UniProtKB/Swiss-Prot
    P28693
    Conserved Domains (5) summary
    cd05065
    Location:625 → 893
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:919 → 989
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:27 → 204
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:445 → 527
    fn3; Fibronectin type III domain
    pfam14575
    Location:556 → 625
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5938662..6036745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015296838.4 → XP_015152324.1  ephrin type-B receptor 2 isoform X3

    UniProtKB/Swiss-Prot
    P28693
    UniProtKB/TrEMBL
    A0A8V0YRG2
    Related
    ENSGALP00010023614.1, ENSGALT00010040649.1
    Conserved Domains (5) summary
    cd05065
    Location:624 → 892
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:918 → 988
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    cd10477
    Location:27 → 204
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:445 → 527
    fn3; Fibronectin type III domain
    pfam14575
    Location:556 → 624
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_015296837.4 → XP_015152323.1  ephrin type-B receptor 2 isoform X2

    UniProtKB/Swiss-Prot
    P28693
    Conserved Domains (7) summary
    cd05065
    Location:640 → 908
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:934 → 1004
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:934 → 1001
    SAM; Sterile alpha motif
    cd10477
    Location:27 → 204
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:445 → 528
    fn3; Fibronectin type III domain
    pfam07714
    Location:645 → 904
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:556 → 640
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  3. XM_015296836.4 → XP_015152322.1  ephrin type-B receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    P28693
    Related
    ENSGALP00010023612.1, ENSGALT00010040647.1
    Conserved Domains (7) summary
    cd05065
    Location:641 → 909
    PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
    cd09552
    Location:935 → 1005
    SAM_EPH-B2; SAM domain of EPH-B2 subfamily of tyrosine kinase receptors
    smart00454
    Location:935 → 1002
    SAM; Sterile alpha motif
    cd10477
    Location:27 → 204
    EphR_LBD_B2; Ligand Binding Domain of Ephrin type-B Receptor 2
    pfam00041
    Location:445 → 528
    fn3; Fibronectin type III domain
    pfam07714
    Location:646 → 905
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:556 → 641
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5973052..6071127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931169.1 → XP_046787125.1  ephrin type-B receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0YRG2

  2. XM_046931168.1 → XP_046787124.1  ephrin type-B receptor 2 isoform X2

  3. XM_046931167.1 → XP_046787123.1  ephrin type-B receptor 2 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28693.3 GenPept UniProtKB/Swiss-Prot:P28693

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