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EGFR epidermal growth factor receptor [ Gallus gallus (chicken) ]

Gene ID: 396494, updated on 11-Apr-2024

Summary

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Symbol
EGFRprovided by CGNC
Full Name
epidermal growth factor receptorprovided by CGNC
Primary source
CGNC:9391
See related
Ensembl:ENSGALG00010007381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
c-erbB
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
36
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (51815505..52072610, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (51870073..52127732, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112531739 Neighboring gene vesicular, overexpressed in cancer, prosurvival protein 1 Neighboring gene LanC like 2 Neighboring gene uncharacterized LOC124417785 Neighboring gene uncharacterized LOC107052614 Neighboring gene uncharacterized LOC124417784 Neighboring gene uncharacterized LOC124418244 Neighboring gene Sec61 translocon gamma subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA methylation down-regulates EGFR expression in chickens. Luo J, et al. Avian Dis, 2013 Jun. PMID 23901748
  2. Studies on epidermal growth factor receptor signaling in vertebrate limb patterning. Omi M, et al. Dev Dyn, 2005 Jun. PMID 15778992
  3. Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha. Lax I, et al. Mol Cell Biol, 1988 May. PMID 3260329, Free PMC Article
  4. c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing. Goodwin RG, et al. Mol Cell Biol, 1986 Sep. PMID 3023963, Free PMC Article
  5. c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. Nilsen TW, et al. Cell, 1985 Jul. PMID 2988784

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data describe the mechanisms of oncogenesis induced in chickens by the myeloblastosis-associated virus 2 retrovirus; analyses identified HRAS, EGFR, MET, and RON as insertionally mutagenized driver genes and characterized the mechanisms of their tumorigenic activation
    Title: HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2.
  2. Epidermal growth factor receptor (EGFR) expression was significantly down-regulated after Marek's disease virus infection. The methylation level of the EGFR promoter was significantly increased at 21 days postinfection.
    Title: DNA methylation down-regulates EGFR expression in chickens.
  3. Data suggest that a conserved mechanism involving EGFR signaling governs proliferation of auditory supporting cells in birds and mammals and may represent a target for future hair cell regeneration strategies.
    Title: EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals.
  4. IL-6 stimulates the 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca(2+)/PKC and EGF receptor in primary cultured chicken hepatocytes.
    Title: Interleukin-6 promotes 2-deoxyglucose uptake through p44/42 MAPKs activation via Ca2+/PKC and EGF receptor in primary cultured chicken hepatocytes.
  5. potential roles for epidermal growth factor receptor signaling in anterior-posterior and dorsal-ventral patterning, apical ectodermal ridges formation, and cell survival during limb morphogenesis
    Title: Studies on epidermal growth factor receptor signaling in vertebrate limb patterning.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
epidermal growth factor receptor
Names
CER
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
NP_990828.2
XP_015136814.1
XP_025002843.1
XP_025002844.1
XP_046766507.1
XP_046766508.1
XP_046766509.1
XP_046766510.1
XP_046766511.1
XP_046766512.1
XP_046766513.1
XP_046766514.1
XP_046775432.1
XP_046775433.1
XP_046775435.1
XP_046775439.1
XP_046775441.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205497.3 → NP_990828.2  epidermal growth factor receptor precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000037
    UniProtKB/TrEMBL
    A0A1D5PKH0, A0A8V0XSQ2
    Related
    ENSGALP00010009726.1, ENSGALT00010017597.1
    Conserved Domains (8) summary
    smart00219
    Location:725 → 980
    TyrKc; Tyrosine kinase, catalytic domain
    cd12093
    Location:647 → 689
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    smart00261
    Location:562 → 611
    FU; Furin-like repeats
    cd00064
    Location:241 → 284
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:716 → 1028
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:197 → 345
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:66 → 178
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:515 → 650
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    51815505..52072610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919485.1 → XP_046775441.1  epidermal growth factor receptor isoform X6

    UniProtKB/TrEMBL
    A0A8V0XUP8
    Related
    ENSGALP00010009724.1, ENSGALT00010017595.1

  2. XM_046919477.1 → XP_046775433.1  epidermal growth factor receptor isoform X3

  3. XM_046919476.1 → XP_046775432.1  epidermal growth factor receptor isoform X3

    Related
    ENSGALP00010009719.1, ENSGALT00010017587.1

  4. XM_046919483.1 → XP_046775439.1  epidermal growth factor receptor isoform X6

    UniProtKB/TrEMBL
    A0A8V0XUP8

  5. XM_015281328.4 → XP_015136814.1  epidermal growth factor receptor isoform X5

    UniProtKB/TrEMBL
    A0A8V0XSQ2
    Related
    ENSGALP00010009721.1, ENSGALT00010017590.1
    Conserved Domains (8) summary
    smart00219
    Location:725 → 980
    TyrKc; Tyrosine kinase, catalytic domain
    cd12093
    Location:647 → 689
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    smart00261
    Location:562 → 611
    FU; Furin-like repeats
    cd00064
    Location:241 → 284
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:716 → 1028
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:197 → 345
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:66 → 178
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:515 → 650
    GF_recep_IV; Growth factor receptor domain IV

  6. XM_025147076.3 → XP_025002844.1  epidermal growth factor receptor isoform X2

    UniProtKB/TrEMBL
    A0A8V0XSQ2
    Conserved Domains (5) summary
    cd12093
    Location:669 → 711
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    cd05108
    Location:738 → 1050
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:217 → 367
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:66 → 178
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:537 → 672
    GF_recep_IV; Growth factor receptor domain IV

  7. XM_025147075.3 → XP_025002843.1  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0XNF4, A0A8V0XSQ2
    Related
    ENSGALP00010009717.1, ENSGALT00010017581.1
    Conserved Domains (5) summary
    cd12093
    Location:669 → 711
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    cd05108
    Location:738 → 1050
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:217 → 367
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:66 → 178
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:537 → 672
    GF_recep_IV; Growth factor receptor domain IV

  8. XM_046919479.1 → XP_046775435.1  epidermal growth factor receptor isoform X4

    Related
    ENSGALP00010009729.1, ENSGALT00010017603.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    51870073..52127732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910558.1 → XP_046766514.1  epidermal growth factor receptor isoform X6

    UniProtKB/TrEMBL
    A0A8V0XUP8

  2. XM_046910554.1 → XP_046766510.1  epidermal growth factor receptor isoform X3

  3. XM_046910553.1 → XP_046766509.1  epidermal growth factor receptor isoform X3

  4. XM_046910557.1 → XP_046766513.1  epidermal growth factor receptor isoform X6

    UniProtKB/TrEMBL
    A0A8V0XUP8

  5. XM_046910556.1 → XP_046766512.1  epidermal growth factor receptor isoform X5

  6. XM_046910552.1 → XP_046766508.1  epidermal growth factor receptor isoform X2

  7. XM_046910551.1 → XP_046766507.1  epidermal growth factor receptor isoform X1

    UniProtKB/TrEMBL
    A0A8V0XNF4

  8. XM_046910555.1 → XP_046766511.1  epidermal growth factor receptor isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13387.1 GenPept UniProtKB/Swiss-Prot:P13387

Gene LinkOut

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