PLAU plasminogen activator, urokinase [Gallus gallus (chicken)] - Gene

Summary

Symbol: PLAUprovided by CGNC
Full Name: plasminogen activator, urokinaseprovided by CGNC
Primary source: CGNC:3784
See related: Ensembl:ENSGALG00010021137
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	6	NC_052537.1 (16272332..16280490, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	6	NC_052578.1 (16258036..16266196, complement)

Chromosome 6 - NC_052537.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

uPA has a key role during CNS development. In association with its receptor, it orchestrates both proteolytic and nonproteolytic events that govern the proper formation of neural networks.
Title: uPA-uPAR molecular complex is involved in cell signaling during neuronal migration and neuritogenesis.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in plasminogen activation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: urokinase-type plasminogen activator

Names: U-plasminogen activator; uPA

NP_990774.3

EC 3.4.21.73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205443.3 → NP_990774.3 urokinase-type plasminogen activator preproprotein

Status: VALIDATED

Source sequence(s)

JAENSK010000231

UniProtKB/Swiss-Prot

P15120

Related

ENSGALP00010030373.1, ENSGALT00010051182.1

Conserved Domains (2) summary

cd00190
Location:173 → 419

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

cl00100
Location:79 → 158

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

16272332..16280490 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

16258036..16266196 complement

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GenBank, FASTA, Sequence Viewer (Graphics)