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VCL vinculin [ Gallus gallus (chicken) ]

Gene ID: 396422, updated on 3-Apr-2024

Summary

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Symbol
VCLprovided by CGNC
Full Name
vinculinprovided by CGNC
Primary source
CGNC:3778
See related
Ensembl:ENSGALG00010022474
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
VINC1
Orthologs
human mouse all
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Genomic context

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See VCL in Genome Data Viewer
Location:
chromosome: 6
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (16171073..16227197, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (16156750..16212942, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111130 Neighboring gene adenosine kinase Neighboring gene adaptor related protein complex 3 mu 1 subunit Neighboring gene uncharacterized LOC124418049 Neighboring gene uncharacterized LOC124418392 Neighboring gene uncharacterized LOC121111131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties. Thompson PM, et al. Structure, 2014 May 6. PMID 24685146, Free PMC Article
  2. The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties. Shen K, et al. J Biol Chem, 2011 Dec 30. PMID 22052910, Free PMC Article
  3. Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner. le Duc Q, et al. J Cell Biol, 2010 Jun 28. PMID 20584916, Free PMC Article
  4. Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini. Palmer SM, et al. J Biol Chem, 2009 Mar 13. PMID 19110481, Free PMC Article
  5. Vinculin tail conformation and self-association is independent of pH and H906 protonation. Palmer SM, et al. Biochemistry, 2008 Nov 25. PMID 18980387

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VASP phosphorylation at Ser(157) mediates its localization at the membrane, but that VASP Ser(157) phosphorylation and membrane localization are not sufficient to activate its actin catalytic activity
    Title: Vasodilator-stimulated phosphoprotein (VASP) regulates actin polymerization and contraction in airway smooth muscle by a vinculin-dependent mechanism.
  2. The importance of the actin-binding site in vinculin, which provide the molecular basis for elucidating additional roles of this interaction, including actin-induced conformational changes that promote actin bundling.
    Title: Identification of an actin binding surface on vinculin that mediates mechanical cell and focal adhesion properties.
  3. Data show that alphaE-catenin D3 binds strongly to vinculin, whereas larger fragments and full-length alphaE-catenin bind approximately 1,000-fold more weakly.
    Title: αE-catenin is an autoinhibited molecule that coactivates vinculin.
  4. The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties.
    Title: The vinculin C-terminal hairpin mediates F-actin bundle formation, focal adhesion, and cell mechanical properties.
  5. ACh stimulation regulates vinculin activation in tracheal smooth muscle via RhoA; vinculin activation facilitates connections between actin filaments and talin-integrin adhesion complexes and mediates the initiation of actin polymerization
    Title: Activation of vinculin induced by cholinergic stimulation regulates contraction of tracheal smooth muscle tissue.
  6. vinculin can link adhesion plaques to the cytoskeleton by initiating the formation of bundled actin filaments or by remodeling existing filaments
    Title: Vinculin nucleates actin polymerization and modifies actin filament structure.
  7. Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini
    Title: Lipid binding to the tail domain of vinculin: specificity and the role of the N and C termini.
  8. role of pH on vinculin tail domain structure and self-association
    Title: Vinculin tail conformation and self-association is independent of pH and H906 protonation.
  9. A critical region of s-alpha-actinin that affects the width and integrity of the Z-line. This region is at least involved in the interaction with vinculin.
    Title: Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes.
  10. study investigated the effect of force on the interaction between talin & vinculin; in the talin-vinculin system, molecular mechanotransduction can occur by protein binding after exposure of buried binding sites
    Title: Stretching single talin rod molecules activates vinculin binding.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
vinculin
Names
meta-vinculin
metavinculin
vinc 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205441.3 → NP_990772.1  vinculin

    See identical proteins and their annotated locations for NP_990772.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000231
    UniProtKB/TrEMBL
    A0A8V0ZQZ7
    Related
    ENSGALP00010033043.1, ENSGALT00010054689.1
    Conserved Domains (1) summary
    pfam01044
    Location:66 → 1066
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16171073..16227197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015288203.3 → XP_015143689.1  vinculin isoform X2

    UniProtKB/Swiss-Prot
    P12003, Q91024
    UniProtKB/TrEMBL
    A0A8V0ZQZ7
    Related
    ENSGALP00010033042.1, ENSGALT00010054688.1
    Conserved Domains (1) summary
    pfam01044
    Location:66 → 1135
    Vinculin; Vinculin family

  2. XM_015288200.4 → XP_015143686.1  vinculin isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZI80, A0A8V0ZQZ7
    Conserved Domains (1) summary
    pfam01044
    Location:66 → 1067
    Vinculin; Vinculin family

  3. XM_040702308.2 → XP_040558242.1  vinculin isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZQZ7

RNA

  1. XR_005860609.2 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16156750..16212942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919961.1 → XP_046775917.1  vinculin isoform X2

    UniProtKB/Swiss-Prot
    P12003, Q91024

  2. XM_046919962.1 → XP_046775918.1  vinculin isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZI80

  3. XM_046919960.1 → XP_046775916.1  vinculin isoform X1

RNA

  1. XR_006934989.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12003.4 GenPept UniProtKB/Swiss-Prot:P12003

Gene LinkOut

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