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PTK2 protein tyrosine kinase 2 [ Gallus gallus (chicken) ]

Gene ID: 396416, updated on 3-Apr-2024

Summary

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Symbol
PTK2provided by CGNC
Full Name
protein tyrosine kinase 2provided by CGNC
Primary source
CGNC:12089
See related
Ensembl:ENSGALG00010009159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
FAK; FAK1; FRNK; p125FAK
Orthologs
human mouse all
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Genomic context

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See PTK2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
45
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (144624642..144822877, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (144995925..145194150, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene microRNA 6572 Neighboring gene argonaute 2, RISC catalytic component Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene uncharacterized LOC121110141 Neighboring gene microRNA 1770

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis of Focal Adhesion Kinase activation on lipid membranes. Acebrón I, et al. EMBO J, 2020 Oct 1. PMID 32779739, Free PMC Article
  2. Structural and mechanistic insights into mechanoactivation of focal adhesion kinase. Bauer MS, et al. Proc Natl Acad Sci U S A, 2019 Apr 2. PMID 30877242, Free PMC Article
  3. A Focal Adhesion Kinase-Derived Peptide Binds the Src SH3 Domain in Two Orientations, As Demonstrated Using Paramagnetic Nuclear Magnetic Resonance. Somireddy Venkata B, et al. Biochemistry, 2016 Jan 12. PMID 26645346
  4. FERM domain interaction with myosin negatively regulates FAK in cardiomyocyte hypertrophy. Santos AM, et al. Nat Chem Biol, 2011 Nov 20. PMID 22101605
  5. Transforming growth factor-beta1-induced satellite cell apoptosis in chickens is associated with beta1 integrin-mediated focal adhesion kinase activation. Li X, et al. Poult Sci, 2009 Aug. PMID 19590089

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis of Focal Adhesion Kinase activation on lipid membranes.
    Title: Structural basis of Focal Adhesion Kinase activation on lipid membranes.
  2. findings strongly support that forces in focal adhesions applied to FAK via known interactions can induce conformational changes, which in turn, trigger focal adhesion signaling.
    Title: Structural and mechanistic insights into mechanoactivation of focal adhesion kinase.
  3. evidence that despite the fact that FAK is in the active, open conformation at CAs, its kinase activity is dispensable for ciliogenesis and ciliary function revealing that FAK plays a scaffolding role in multiciliated cells.
    Title: Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells.
  4. FAK-derived peptide binds the SH3 domain in two orientations.
    Title: A Focal Adhesion Kinase-Derived Peptide Binds the Src SH3 Domain in Two Orientations, As Demonstrated Using Paramagnetic Nuclear Magnetic Resonance.
  5. findings uncover an inhibitory interaction between the FAK FERM domain and sarcomeric myosin that presents potential opportunities to modulate the cardiac hypertrophic response through changes in FAK activity
    Title: FERM domain interaction with myosin negatively regulates FAK in cardiomyocyte hypertrophy.
  6. These data suggested that the apoptotic effect of transforming growth factor-beta1 on satellite cells is likely associated with a beta1 integrin-mediated focal adhesion kinase signaling pathway.
    Title: Transforming growth factor-beta1-induced satellite cell apoptosis in chickens is associated with beta1 integrin-mediated focal adhesion kinase activation.
  7. inactivation of p38MAPK down-regulated the level of MMP-2 mRNA and activity, and increased mesenchymal cell condensation in parallel with enhanced phosphorylation of FAK
    Title: MMP-2 functions as a negative regulator of chondrogenic cell condensation via down-regulation of the FAK-integrin beta1 interaction.
  8. Src-dependent FAK phosphorylation is required for focal adhesion turnover and cell migration
    Title: SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling.
  9. structural features suggest the possibility that protein interactions of the FAK FERM domain can be regulated by binding of Src kinases to the linker segment
    Title: Crystal structure of the FERM domain of focal adhesion kinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal complex assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
focal adhesion kinase 1
Names
FADK 1
PTK2 protein tyrosine kinase 2
focal adhesion kinase-related nonkinase
p41/p43FRNK
pp125FAK
NP_001383479.1
NP_001383480.1
NP_001383481.1
NP_001383482.1
NP_001383483.1
NP_001383484.1
NP_001383485.1
NP_001383486.1
XP_046766445.1
XP_046766446.1
XP_046766447.1
XP_046766448.1
XP_046766449.1
XP_046766450.1
XP_046766452.1
XP_046766453.1
XP_046766454.1
XP_046766455.1
XP_046766456.1
XP_046766457.1
XP_046766458.1
XP_046766459.1
XP_046766460.1
XP_046766461.1
XP_046766462.1
XP_046766463.1
XP_046766464.1
XP_046766465.1
XP_046766466.1
XP_046766467.1
XP_046766468.1
XP_046766469.1
XP_046766470.1
XP_046766471.1
XP_046766472.1
XP_046766473.1
XP_046766474.1
XP_046766475.1
XP_046766476.1
XP_046766477.1
XP_046766478.1
XP_046766479.1
XP_046775221.1
XP_046775232.1
XP_046775243.1
XP_046775244.1
XP_046775246.1
XP_046775247.1
XP_046775248.1
XP_046775250.1
XP_046775252.1
XP_046775253.1
XP_046775254.1
XP_046775256.1
XP_046775258.1
XP_046775264.1
XP_046775269.1
XP_046775274.1
XP_046775279.1
XP_046775283.1
XP_046775286.1
XP_046775296.1
XP_046775307.1
XP_046775315.1
XP_046775322.1
XP_046775324.1
XP_046775329.1
XP_046775332.1
XP_046775336.1
XP_046775340.1
XP_046775347.1
XP_046775351.1
XP_046775352.1
XP_046775353.1
XP_046775354.1
XP_046775356.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396550.1 → NP_001383479.1  focal adhesion kinase 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0Y0S6
    Conserved Domains (3) summary
    cd05056
    Location:461 → 725
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:82 → 304
    B41; Band 4.1 homologues
    cd13190
    Location:300 → 410
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  2. NM_001396551.1 → NP_001383480.1  focal adhesion kinase 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0Y0S1
    Related
    ENSGALP00010012543.1, ENSGALT00010021907.1
    Conserved Domains (3) summary
    cd05056
    Location:459 → 723
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:80 → 302
    B41; Band 4.1 homologues
    cd13190
    Location:298 → 408
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  3. NM_001396552.1 → NP_001383481.1  focal adhesion kinase 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0XWD5
    Conserved Domains (3) summary
    cd05056
    Location:428 → 692
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  4. NM_001396553.1 → NP_001383482.1  focal adhesion kinase 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0Y517
    Conserved Domains (3) summary
    cd05056
    Location:422 → 686
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  5. NM_001396554.1 → NP_001383483.1  focal adhesion kinase 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0Y512
    Conserved Domains (3) summary
    cd05056
    Location:415 → 679
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  6. NM_001396555.1 → NP_001383484.1  focal adhesion kinase 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0Y512
    Related
    ENSGALP00010012583.1, ENSGALT00010021968.1
    Conserved Domains (3) summary
    cd05056
    Location:415 → 679
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  7. NM_001396556.1 → NP_001383485.1  focal adhesion kinase 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0Y512
    Related
    ENSGALP00010012593.1, ENSGALT00010021982.1
    Conserved Domains (3) summary
    cd05056
    Location:415 → 679
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

  8. NM_001396557.1 → NP_001383486.1  focal adhesion kinase 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000044
    UniProtKB/TrEMBL
    A0A8V0Y512
    Related
    ENSGALP00010012598.1, ENSGALT00010021988.1
    Conserved Domains (3) summary
    cd05056
    Location:415 → 679
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:36 → 258
    B41; Band 4.1 homologues
    cd13190
    Location:254 → 364
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    144624642..144822877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919359.1 → XP_046775315.1  focal adhesion kinase 1 isoform X21

  2. XM_046919376.1 → XP_046775332.1  focal adhesion kinase 1 isoform X21

  3. XM_046919380.1 → XP_046775336.1  focal adhesion kinase 1 isoform X21

  4. XM_046919351.1 → XP_046775307.1  focal adhesion kinase 1 isoform X21

    Related
    ENSGALP00010012572.1, ENSGALT00010021954.1

  5. XM_046919366.1 → XP_046775322.1  focal adhesion kinase 1 isoform X21

    Related
    ENSGALP00010012559.1, ENSGALT00010021936.1

  6. XM_046919373.1 → XP_046775329.1  focal adhesion kinase 1 isoform X21

  7. XM_046919368.1 → XP_046775324.1  focal adhesion kinase 1 isoform X21

  8. XM_046919384.1 → XP_046775340.1  focal adhesion kinase 1 isoform X21

  9. XM_046919290.1 → XP_046775246.1  focal adhesion kinase 1 isoform X5

  10. XM_046919395.1 → XP_046775351.1  focal adhesion kinase 1 isoform X21

  11. XM_046919330.1 → XP_046775286.1  focal adhesion kinase 1 isoform X19

  12. XM_046919327.1 → XP_046775283.1  focal adhesion kinase 1 isoform X18

  13. XM_046919400.1 → XP_046775356.1  focal adhesion kinase 1 isoform X25

    UniProtKB/TrEMBL
    A0A8V0Y9A0
    Related
    ENSGALP00010012555.1, ENSGALT00010021932.1

  14. XM_046919294.1 → XP_046775250.1  focal adhesion kinase 1 isoform X8

    Related
    ENSGALP00010012548.1, ENSGALT00010021919.1

  15. XM_046919323.1 → XP_046775279.1  focal adhesion kinase 1 isoform X17

    UniProtKB/TrEMBL
    A0A8V0Y4W9
    Related
    ENSGALP00010012552.1, ENSGALT00010021927.1

  16. XM_046919318.1 → XP_046775274.1  focal adhesion kinase 1 isoform X16

  17. XM_046919308.1 → XP_046775264.1  focal adhesion kinase 1 isoform X14

  18. XM_046919300.1 → XP_046775256.1  focal adhesion kinase 1 isoform X12

  19. XM_046919313.1 → XP_046775269.1  focal adhesion kinase 1 isoform X15

  20. XM_046919302.1 → XP_046775258.1  focal adhesion kinase 1 isoform X13

  21. XM_046919298.1 → XP_046775254.1  focal adhesion kinase 1 isoform X11

  22. XM_046919297.1 → XP_046775253.1  focal adhesion kinase 1 isoform X10

  23. XM_046919292.1 → XP_046775248.1  focal adhesion kinase 1 isoform X7

  24. XM_046919287.1 → XP_046775243.1  focal adhesion kinase 1 isoform X3

  25. XM_046919291.1 → XP_046775247.1  focal adhesion kinase 1 isoform X6

  26. XM_046919288.1 → XP_046775244.1  focal adhesion kinase 1 isoform X4

  27. XM_046919276.1 → XP_046775232.1  focal adhesion kinase 1 isoform X2

  28. XM_046919265.1 → XP_046775221.1  focal adhesion kinase 1 isoform X1

  29. XM_046919391.1 → XP_046775347.1  focal adhesion kinase 1 isoform X21

  30. XM_046919340.1 → XP_046775296.1  focal adhesion kinase 1 isoform X20

  31. XM_046919296.1 → XP_046775252.1  focal adhesion kinase 1 isoform X9

  32. XM_046919397.1 → XP_046775353.1  focal adhesion kinase 1 isoform X23

  33. XM_046919396.1 → XP_046775352.1  focal adhesion kinase 1 isoform X22

  34. XM_046919398.1 → XP_046775354.1  focal adhesion kinase 1 isoform X24

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    144995925..145194150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910511.1 → XP_046766467.1  focal adhesion kinase 1 isoform X21

  2. XM_046910515.1 → XP_046766471.1  focal adhesion kinase 1 isoform X21

  3. XM_046910516.1 → XP_046766472.1  focal adhesion kinase 1 isoform X21

  4. XM_046910510.1 → XP_046766466.1  focal adhesion kinase 1 isoform X21

  5. XM_046910512.1 → XP_046766468.1  focal adhesion kinase 1 isoform X21

  6. XM_046910514.1 → XP_046766470.1  focal adhesion kinase 1 isoform X21

  7. XM_046910513.1 → XP_046766469.1  focal adhesion kinase 1 isoform X21

  8. XM_046910517.1 → XP_046766473.1  focal adhesion kinase 1 isoform X21

  9. XM_046910493.1 → XP_046766449.1  focal adhesion kinase 1 isoform X5

  10. XM_046910519.1 → XP_046766475.1  focal adhesion kinase 1 isoform X21

  11. XM_046910508.1 → XP_046766464.1  focal adhesion kinase 1 isoform X19

  12. XM_046910507.1 → XP_046766463.1  focal adhesion kinase 1 isoform X18

  13. XM_046910523.1 → XP_046766479.1  focal adhesion kinase 1 isoform X25

    UniProtKB/TrEMBL
    A0A8V0Y9A0

  14. XM_046910497.1 → XP_046766453.1  focal adhesion kinase 1 isoform X8

  15. XM_046910506.1 → XP_046766462.1  focal adhesion kinase 1 isoform X17

    UniProtKB/TrEMBL
    A0A8V0Y4W9

  16. XM_046910505.1 → XP_046766461.1  focal adhesion kinase 1 isoform X16

  17. XM_046910503.1 → XP_046766459.1  focal adhesion kinase 1 isoform X14

  18. XM_046910501.1 → XP_046766457.1  focal adhesion kinase 1 isoform X12

  19. XM_046910504.1 → XP_046766460.1  focal adhesion kinase 1 isoform X15

  20. XM_046910502.1 → XP_046766458.1  focal adhesion kinase 1 isoform X13

  21. XM_046910500.1 → XP_046766456.1  focal adhesion kinase 1 isoform X11

  22. XM_046910499.1 → XP_046766455.1  focal adhesion kinase 1 isoform X10

  23. XM_046910496.1 → XP_046766452.1  focal adhesion kinase 1 isoform X7

  24. XM_046910491.1 → XP_046766447.1  focal adhesion kinase 1 isoform X3

  25. XM_046910494.1 → XP_046766450.1  focal adhesion kinase 1 isoform X6

  26. XM_046910492.1 → XP_046766448.1  focal adhesion kinase 1 isoform X4

  27. XM_046910490.1 → XP_046766446.1  focal adhesion kinase 1 isoform X2

  28. XM_046910489.1 → XP_046766445.1  focal adhesion kinase 1 isoform X1

  29. XM_046910518.1 → XP_046766474.1  focal adhesion kinase 1 isoform X21

  30. XM_046910509.1 → XP_046766465.1  focal adhesion kinase 1 isoform X20

  31. XM_046910498.1 → XP_046766454.1  focal adhesion kinase 1 isoform X9

  32. XM_046910521.1 → XP_046766477.1  focal adhesion kinase 1 isoform X23

  33. XM_046910520.1 → XP_046766476.1  focal adhesion kinase 1 isoform X22

  34. XM_046910522.1 → XP_046766478.1  focal adhesion kinase 1 isoform X24

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_205435.1: Suppressed sequence

    Description
    NM_205435.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00944.2 GenPept UniProtKB/Swiss-Prot:Q00944

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