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FGF2 fibroblast growth factor 2 [ Gallus gallus (chicken) ]

Gene ID: 396413, updated on 5-Mar-2024

Summary

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Symbol
FGF2provided by CGNC
Full Name
fibroblast growth factor 2provided by CGNC
Primary source
CGNC:8970
See related
Ensembl:ENSGALG00010004219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
BFGF; FGF-2; HBGF-2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (53088595..53118677, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (53091172..53121236, complement)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112532400 Neighboring gene sprouty RTK signaling antagonist 1 Neighboring gene spermatogenesis associated 5 Neighboring gene nudix hydrolase 6 Neighboring gene Bardet-Biedl syndrome 12 Neighboring gene centrin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system. Krejci E, et al. Physiol Res, 2016 Jul 18. PMID 27070743
  2. Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis. Wierzbicki M, et al. Int J Nanomedicine, 2013. PMID 24039425, Free PMC Article
  3. Calcium signals induced by FGF-2 in parasympathetic neurons: role of second messenger pathways. Zamburlin P, et al. Neurosci Lett, 2012 Aug 8. PMID 22732451
  4. Basic fibroblast growth factor increases the precursor pool of photoreceptors, but inhibits their differentiation and apoptosis in chicken retinal reaggregates. Frohns F, et al. Eur J Neurosci, 2009 May. PMID 19453639
  5. Specificity of the second messenger pathways involved in basic fibroblast growth factor-induced survival and neurite growth in chick ciliary ganglion neurons. Gilardino A, et al. J Neurosci Res, 2009 Oct. PMID 19405103

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIF and bFGF enhanced chicken primordial follicle activation by Wnt/beta-catenin pathway.
    Title: LIF and bFGF enhanced chicken primordial follicle activation by Wnt/β-catenin pathway.
  2. synthesis increased in embryonic ventricular cardiomyocytes in response to increased stretch due to pressure overload
    Title: Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system.
  3. BFGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons.
    Title: Basic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons.
  4. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf.
    Title: Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling.
  5. Application of nanoparticles significantly downregulated gene and protein expression of the proangiogenic basic fibroblast growth factor, indicating that both diamond and graphite nanoparticles inhibit angiogenesis.
    Title: Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis.
  6. We propose that this complex behaviour can be due to a perturbation in PIP(2) levels at the plasmamembrane.
    Title: Calcium signals induced by FGF-2 in parasympathetic neurons: role of second messenger pathways.
  7. BFGF promotes cell survival via the PI3-K pathway and neurite outgrowth via PI3-K, MAPK, and phospholipase Cgamma pathways.
    Title: Specificity of the second messenger pathways involved in basic fibroblast growth factor-induced survival and neurite growth in chick ciliary ganglion neurons.
  8. Sox2 can initiate a reprogramming of retinal pigment epithelium cells to differentiate toward retinal neurons and may engage bFGF during the process.
    Title: Reprogramming retinal pigment epithelium to differentiate toward retinal neurons with Sox2.
  9. in a three-dimensional retinal tissue context, FGF-2 restricts the pool of photoreceptor cells in favour of cells of the inner retina, increases and maintains their precursor pool, delays their differentiation, and also protects them from apoptosis.
    Title: Basic fibroblast growth factor increases the precursor pool of photoreceptors, but inhibits their differentiation and apoptosis in chicken retinal reaggregates.
  10. expression of the bFGF gene and protein is low and decreases in the healing tendon
    Title: Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor 2
Names
basic fibroblast growth factor
fibroblast growth factor 2 (basic)
heparin-binding growth factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205433.2 → NP_990764.1  fibroblast growth factor 2

    See identical proteins and their annotated locations for NP_990764.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000074
    UniProtKB/Swiss-Prot
    P48800
    Related
    ENSGALP00010005751.1, ENSGALT00010009865.1
    Conserved Domains (1) summary
    pfam00167
    Location:32 → 152
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    53088595..53118677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046939941.1 → XP_046795897.1  fibroblast growth factor 2 isoform X1

    UniProtKB/TrEMBL
    F1NUZ0, Q07659

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    53091172..53121236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915596.1 → XP_046771552.1  fibroblast growth factor 2 isoform X1

    UniProtKB/TrEMBL
    F1NUZ0, Q07659
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48800.1 GenPept UniProtKB/Swiss-Prot:P48800

Gene LinkOut

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