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CSK C-terminal Src kinase [ Gallus gallus (chicken) ]

Gene ID: 396396, updated on 3-Apr-2024

Summary

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Official Symbol
CSKprovided by CGNC
Official Full Name
C-terminal Src kinaseprovided by CGNC
Primary source
CGNC:902
See related
Ensembl:ENSGALG00010023593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
c-Src
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (2452714..2461276, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (2325999..2334622, complement)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene unc-51 like kinase 3 Neighboring gene complexin 3 Neighboring gene cytochrome P450, family 1, subfamily A, polypeptide 2 Neighboring gene cytochrome P450, family 1, subfamily A, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation. Bacarizo J, et al. PLoS One, 2014. PMID 25490095, Free PMC Article
  2. Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II. Bacarizo J, et al. Acta Crystallogr D Biol Crystallogr, 2013 May. PMID 23633584
  3. Myristoylation and membrane binding regulate c-Src stability and kinase activity. Patwardhan P, et al. Mol Cell Biol, 2010 Sep. PMID 20584982, Free PMC Article
  4. c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling. Donepudi M, et al. Cell Signal, 2008 Jul. PMID 18448311, Free PMC Article
  5. Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein. Sabe H, et al. Proc Natl Acad Sci U S A, 1992 Mar 15. PMID 1372437, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. electrostatic interactions and solvation of residues close to the folding nucleation site of the c-Src-SH3 domain might play an important role during the folding reaction and the amyloid fibril formation
    Title: Electrostatic effects in the folding of the SH3 domain of the c-Src tyrosine kinase: pH-dependence in 3D-domain swapping and amyloid formation.
  2. crystal structures of the c-Src SH3 domain in complex with two high-affinity peptides
    Title: Atomic resolution structures of the c-Src SH3 domain in complex with two high-affinity peptides from classes I and II.
  3. Myristoylation exerts a positive effect on c-Src kinase activity.
    Title: Myristoylation and membrane binding regulate c-Src stability and kinase activity.
  4. These data suggest that the synergy between c-Src and EGFR also occurs as these two kinases traffic together, and that their co-localization promotes EGFR-mediated signaling.
    Title: c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling.
  5. suppression of c-Src interferes with osteoclast bone resorption by disrupting functional co-localization of proton pump and CLIC-5b.
    Title: c-Src control of chloride channel support for osteoclast HCl transport and bone resorption.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Fc receptor mediated stimulatory signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase CSK
Names
C-Src kinase
c-src tyrosine kinase
protein kinase
src kinase
NP_990756.2
XP_015134280.1
XP_040562172.1
XP_046780565.1
XP_046780566.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205425.2 → NP_990756.2  tyrosine-protein kinase CSK

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000245
    Related
    ENSGALP00010034899.1, ENSGALT00010057429.1
    Conserved Domains (3) summary
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
    cl21453
    Location:188 → 443
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2452714..2461276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015278794.4 → XP_015134280.1  tyrosine-protein kinase CSK isoform X1

    UniProtKB/Swiss-Prot
    P41239
    Related
    ENSGALP00010034911.1, ENSGALT00010057447.1
    Conserved Domains (3) summary
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
    cl21453
    Location:188 → 443
    PKc_like; Protein Kinases, catalytic domain

  2. XM_040706238.2 → XP_040562172.1  tyrosine-protein kinase CSK isoform X1

    UniProtKB/Swiss-Prot
    P41239
    Conserved Domains (3) summary
    cd09937
    Location:78 → 175
    SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
    cd11769
    Location:11 → 67
    SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
    cl21453
    Location:188 → 443
    PKc_like; Protein Kinases, catalytic domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2325999..2334622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924609.1 → XP_046780565.1  tyrosine-protein kinase CSK isoform X1

  2. XM_046924610.1 → XP_046780566.1  tyrosine-protein kinase CSK isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41239.1 GenPept UniProtKB/Swiss-Prot:P41239

Gene LinkOut

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