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HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 [ Gallus gallus (chicken) ]

Gene ID: 396379, updated on 3-Apr-2024

Summary

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Symbol
HMGCS1provided by CGNC
Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 1provided by CGNC
Primary source
CGNC:49779
See related
Ensembl:ENSGALG00010014334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Z
Exon count:
12
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (14183309..14199586, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (14183309..14199586, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107049314 Neighboring gene zinc finger protein 131 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene uncharacterized LOC107051936 Neighboring gene uncharacterized LOC121108620

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Avian cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase: evaluation of the role of cysteines in reaction chemistry. Misra I, et al. Biochim Biophys Acta, 1995 Mar 15. PMID 7696316
  2. Avian liver 3-hydroxy-3-methylglutaryl-CoA synthase: distinct genes encode the cholesterogenic and ketogenic isozymes. Kattar-Cooley PA, et al. Arch Biochem Biophys, 1990 Dec. PMID 1980405
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Names
3-hydroxy-3-methylglutaryl coenzyme A synthase
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
HMG-CoA synthase
NP_990742.2
XP_015132738.4
XP_015132739.4
XP_015132740.4
XP_015132741.1
XP_040511397.1
XP_040511398.1
XP_046790835.1
XP_046790836.1
XP_046790837.1
XP_046790838.1
XP_046790839.1
XP_046790840.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205411.2 → NP_990742.2  hydroxymethylglutaryl-CoA synthase, cytoplasmic

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000089
    UniProtKB/Swiss-Prot
    P23228
    UniProtKB/TrEMBL
    A0A1L1RZ64
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 470
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    14183309..14199586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040655464.2 → XP_040511398.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    UniProtKB/Swiss-Prot
    P23228
    UniProtKB/TrEMBL
    A0A1L1RZ64
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 470
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  2. XM_015277254.4 → XP_015132740.4  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

  3. XM_015277255.4 → XP_015132741.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    UniProtKB/Swiss-Prot
    P23228
    UniProtKB/TrEMBL
    A0A1L1RZ64
    Related
    ENSGALP00010020284.1, ENSGALT00010034537.1
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 470
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  4. XM_015277253.4 → XP_015132739.4  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    Related
    ENSGALP00010020281.1, ENSGALT00010034532.1

  5. XM_015277252.4 → XP_015132738.4  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

  6. XM_040655463.2 → XP_040511397.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    UniProtKB/Swiss-Prot
    P23228
    UniProtKB/TrEMBL
    A0A1L1RZ64
    Related
    ENSGALP00010020279.1, ENSGALT00010034528.1
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 470
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    14183309..14199586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934883.1 → XP_046790839.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A1L1RZ64

  2. XM_046934881.1 → XP_046790837.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

  3. XM_046934882.1 → XP_046790838.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A1L1RZ64

  4. XM_046934880.1 → XP_046790836.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

  5. XM_046934879.1 → XP_046790835.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

  6. XM_046934884.1 → XP_046790840.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A1L1RZ64
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23228.1 GenPept UniProtKB/Swiss-Prot:P23228

Gene LinkOut

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