CCND1 cyclin D1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CCND1provided by CGNC
Full Name: cyclin D1provided by CGNC
Primary source: CGNC:5701
See related: Ensembl:ENSGALG00010025419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (17081391..17097705)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (17042768..17059093)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cell cycle inhibitor p21 was significantly increased, whereas cyclin D1, a cell cycle promoter, decreased in sustained hyperglycemia compared with controls
Title: Hyperglycemia slows embryonic growth and suppresses cell cycle via cyclin D1 and p21.
motoneuron progenitors in the embryonic spinal cord persistently express Cyclin D1 during the initial phase of differentiation, while down-regulating Cyclin D2
Title: Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner.
Pitx2 activity directs asymmetrical gonad morphogenesis by controlling mitotic spindle orientation of the developing gonad cortex and how, by modulating cyclinD1 expression during asymmetric ovarian development
Title: Pitx2 regulates gonad morphogenesis.
FGF signaling maintains cyclin D2 in the immature caudal neural epithelium, while Shh activates cyclin D1 in the neural groove.
Title: Specific regulation of cyclins D1 and D2 by FGF and Shh signaling coordinates cell cycle progression, patterning, and differentiation during early steps of spinal cord development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: G1/S-specific cyclin-D1

Names: cyclin D1 (PRAD1: parathyroid adenomatosis 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396513.1 → NP_001383442.1 G1/S-specific cyclin-D1 isoform 2

Status: VALIDATED

Source sequence(s)

JAENSK010000214

Conserved Domains (1) summary

cl40454
Location:2 → 140

CYCLIN_SF; Cyclin box fold superfamily
NM_205381.2 → NP_990712.2 G1/S-specific cyclin-D1 isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000214

UniProtKB/Swiss-Prot

P55169

UniProtKB/TrEMBL

F1NS84

Related

ENSGALP00010038338.1, ENSGALT00010062057.1

Conserved Domains (2) summary

cd20573
Location:3 → 151

CYCLIN_CCND1_rpt1; first cyclin box found in G1/S-specific cyclin-D1 (CCND1)

cd20576
Location:156 → 265

CYCLIN_CCND1_rpt2; second cyclin box found in G1/S-specific cyclin-D1 (CCND1)