FGF8 fibroblast growth factor 8 [Gallus gallus (chicken)] - Gene

Summary

Symbol: FGF8provided by CGNC
Full Name: fibroblast growth factor 8provided by CGNC
Primary source: CGNC:49748
See related: Ensembl:ENSGALG00010021040
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: FGF-8
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	6	NC_052537.1 (23501490..23509886)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	6	NC_052578.1 (23392753..23401155)

Chromosome 6 - NC_052537.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a precise and dynamic expression pattern of fibroblast growth factor 8 (Fgf8) was found in the high acuity area anlage, which was regulated by enzymes that degrade retinoic acid (RA).
Title: Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina.
FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation.
Title: FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis.
Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules
Title: Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules.
also enhances FGF8 activity while inhibiting BMP5 and WNT3a signaling
Title: Extracellular matrix protein anosmin promotes neural crest formation and regulates FGF, BMP, and WNT activities.
Data show that ectopic FGF8 overexpression in the ventral pharynx of HH16-18 embryos caused a dramatic increase in thickness of the mesenchyme.
Title: FGF8 signaling is chemotactic for cardiac neural crest cells.
Results demonstrate that FGF8 induces Tbx22 in the early face while BMP4 represses and thus restricts its expression. This regulation is conserved between chicken and mouse.
Title: Regulation of Tbx22 during facial and palatal development.
FGF8 increased smooth muscle differentiation.
Title: Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate.
Data show that BMP4 and Shh constitute a dorsal-ventral signaling system together with FGF8.
Title: Coordinated regulation of dorsal bone morphogenetic protein 4 and ventral Sonic hedgehog signaling specifies the dorso-ventral polarity in the optic vesicle and governs ocular morphogenesis through fibroblast growth factor 8 upregulation.
sufficient, but not necessary, for ANTXR1 expression in Hamburger and Hamilton stage 18 facial mesenchyme
Title: Expression and regulation of ANTXR1 in the chick embryo.
'Prolonged' activation of ERK by misexpression of Fgf8b and dominant-negative Sprouty2 (dnSprouty2) did not change the fate of the mesencephalic alar plate.
Title: Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity.

Submit: New GeneRIF Correction See all GeneRIFs (27)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables type 1 fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables type 2 fibroblast growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in embryonic heart tube development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in limb morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fibroblast growth factor 8

Names: HBGF-8; fibroblast growth factor 8 (androgen-induced); heparin-binding growth factor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012767.2 → NP_001012785.2 fibroblast growth factor 8 precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000232

UniProtKB/Swiss-Prot

Q90722

UniProtKB/TrEMBL

F6SMK2, Q4R0X9

Related

ENSGALP00010030097.1, ENSGALT00010050906.1

Conserved Domains (1) summary

pfam00167
Location:52 → 175

FGF; Fibroblast growth factor