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Prosbeta2 Proteasome beta2 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39628, updated on 5-May-2024

Summary

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Official Symbol
Prosbeta2provided by FlyBase
Official Full Name
Proteasome beta2 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0023174
Locus tag
Dmel_CG3329
See related
AllianceGenome:FB:FBgn0023174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
3329; anon-EST:fe1E6; anon-EST:fe1G6; b2; beta 2; Beta 2 subunit; beta-2; Beta-2; beta2; beta2_dm; B[[2]]; CG3329; Dmel\CG3329; DTS-7; DTS57; Dts7; DTS7; l(3)DTS7; prosbeta; Prosbeta; Prosbeta 2; prosbeta2; ProsBeta2; PROSbeta2
Summary
Predicted to enable endopeptidase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head and organism. Orthologous to several human genes including PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
71B1-71B1; 3-42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14999951..15001319)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14993051..14994419)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene minidiscs Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene Reversion-inducing-cysteine-rich protein with kazal motifs Neighboring gene Synaptotagmin beta Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 12-related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhancing the stability and ecological safety of mass-reared transgenic strains for field release by redundant conditional lethality systems. Handler AM. Insect Sci, 2016 Apr. PMID 26097098
  2. Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster. Murali A, et al. Neurobiol Dis, 2014 Jul. PMID 24686303
  3. Oxidative stress adaptation with acute, chronic, and repeated stress. Pickering AM, et al. Free Radic Biol Med, 2013 Feb. PMID 23142766, Free PMC Article
  4. Proteasome inhibition induces developmentally deregulated programs of apoptotic and autophagic cell death during Drosophila melanogaster oogenesis. Velentzas PD, et al. Cell Biol Int, 2011 Jan. PMID 20819072
  5. Targeted expression of dominant negative proteasome mutants in Drosophila melanogaster. Belote JM, et al. Genesis, 2002 Sep-Oct. PMID 12324954

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These detoxification results represent the first evidence that Prosbeta2 plays a role in the detoxification of DM, which may provide new idea and target for studying the molecular mechanisms of insect resistance
    Title: Identification of proteasome subunit beta type 2 associated with deltamethrin detoxification in Drosophila Kc cells by cDNA microarray analysis and bioassay analyses.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity IC
Inferred by Curator
more info
 PubMed 
enables endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome beta2 subunit
Names
20s proteasome
CG3329-PA
Prosbeta2-PA
anon-fast-evolving-1E6
anon-fast-evolving-1G6
b2 subunit
beta2
beta2 proteosome subunit
beta2 subunit
proteasome beta2
NP_524076.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14999951..15001319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079352.4 → NP_524076.2  proteasome beta2 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524076.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17312, Q9VUJ1
    Related
    FBpp0075382
    Conserved Domains (3) summary
    COG0638
    Location:42 → 232
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03763
    Location:42 → 228
    proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    pfam12465
    Location:232 → 264
    Pr_beta_C; Proteasome beta subunits C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17311 O17311
O17312 O17312
Q9VUJ1 Q9VUJ1

Gene LinkOut

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