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CDK1 cyclin dependent kinase 1 [ Gallus gallus (chicken) ]

Gene ID: 396252, updated on 3-Apr-2024

Summary

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Symbol
CDK1provided by CGNC
Full Name
cyclin dependent kinase 1provided by CGNC
Primary source
CGNC:2236
See related
Ensembl:ENSGALG00010009597
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CDC2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (9395887..9403898, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (9274606..9283547, complement)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene ciliary associated calcium binding coiled-coil 1 Neighboring gene 5S ribosomal RNA Neighboring gene Rho related BTB domain containing 1 Neighboring gene ankyrin 3 Neighboring gene uncharacterized LOC121111153 Neighboring gene uncharacterized LOC101749147 Neighboring gene coiled-coil domain containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and developmental expression of the chicken CDC2 kinase. Krek W, et al. EMBO J, 1989 Oct. PMID 2684635, Free PMC Article
  2. Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. Krek W, et al. EMBO J, 1991 Feb. PMID 1846803, Free PMC Article
  3. Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle. Chiu HC, et al. PLoS One, 2016. PMID 27603133, Free PMC Article
  4. Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system. Nasheuer HP, et al. Chromosoma, 1992. PMID 1337880
  5. Cell cycle transition under stress conditions controlled by vertebrate heat shock factors. Nakai A, et al. EMBO J, 2001 Jun 1. PMID 11387221, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p17 suppresses both CDK1 and Plk1functions, disrupts vimentin phosphorylation, causes G2/M cell cycle arrest and thus benefits virus replication.
    Title: Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 1
Names
cell division control protein 2 homolog
cell division cycle 2, G1 to S and G2 to M
cell division protein kinase 1
p34 protein kinase
NP_990645.2
XP_015143549.1
XP_015143550.1
XP_046775892.1
XP_046775893.1
XP_046775894.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205314.2 → NP_990645.2  cyclin-dependent kinase 1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000227
    UniProtKB/Swiss-Prot
    P13863
    UniProtKB/TrEMBL
    F1NBD7
    Related
    ENSGALP00010013220.1, ENSGALT00010022879.1
    Conserved Domains (1) summary
    cd07861
    Location:3 → 287
    STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9395887..9403898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015288063.4 → XP_015143549.1  cyclin-dependent kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    P13863
    UniProtKB/TrEMBL
    F1NBD7
    Conserved Domains (1) summary
    cd07861
    Location:3 → 287
    STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

  2. XM_015288064.4 → XP_015143550.1  cyclin-dependent kinase 1 isoform X1

    UniProtKB/Swiss-Prot
    P13863
    UniProtKB/TrEMBL
    F1NBD7
    Conserved Domains (1) summary
    cd07861
    Location:3 → 287
    STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9274606..9283547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919936.1 → XP_046775892.1  cyclin-dependent kinase 1 isoform X1

    UniProtKB/TrEMBL
    F1NBD7

  2. XM_046919937.1 → XP_046775893.1  cyclin-dependent kinase 1 isoform X1

    UniProtKB/TrEMBL
    F1NBD7

  3. XM_046919938.1 → XP_046775894.1  cyclin-dependent kinase 1 isoform X1

    UniProtKB/TrEMBL
    F1NBD7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13863.1 GenPept UniProtKB/Swiss-Prot:P13863

Gene LinkOut

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