THRA thyroid hormone receptor alpha [Gallus gallus (chicken)] - Gene

Summary

Symbol: THRAprovided by CGNC
Full Name: thyroid hormone receptor alphaprovided by CGNC
Primary source: CGNC:155
See related: Ensembl:ENSGALG00010024621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: NR1A1
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 27

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	27	NC_052558.1 (4330936..4344802)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	27	NC_052599.1 (5492776..5505207)

Chromosome 27 - NC_052558.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in thyroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: thyroid hormone receptor alpha

Names: c-erb-A protein; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor beta; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205313.2 → NP_990644.1 thyroid hormone receptor alpha

See identical proteins and their annotated locations for NP_990644.1

Status: VALIDATED

Source sequence(s)

AADN05000735

UniProtKB/Swiss-Prot

P04625

UniProtKB/TrEMBL

A0A8V1A0W0

Related

ENSGALP00010036852.1, ENSGALT00010060092.1

Conserved Domains (2) summary

cd06935
Location:160 → 402

NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors

cd06961
Location:50 → 136

NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers