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RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Gallus gallus (chicken) ]

Gene ID: 396245, updated on 5-Mar-2024

Summary

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Symbol
RAF1provided by CGNC
Full Name
Raf-1 proto-oncogene, serine/threonine kinaseprovided by CGNC
Primary source
CGNC:3714
See related
Ensembl:ENSGALG00010027930
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MIL
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (5135889..5204860, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (5160148..5229102, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene peroxisome proliferator-activated receptor gamma Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin ring finger protein 2 Neighboring gene CCHC-type zinc finger nucleic acid binding protein Neighboring gene atherin-like Neighboring gene ISY1 splicing factor homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development. Magariños M, et al. PLoS One, 2010 Dec 28. PMID 21203386, Free PMC Article
  2. A revised and complete map of the chicken c-mil/raf-1 locus. Brummer T, et al. Oncogene, 2004 Apr 15. PMID 14968114
  3. Primary structure of the chicken c-mil protein:identification of domains shared with or absent from the retroviral v-mil protein. Koenen M, et al. Oncogene, 1988 Feb. PMID 3285296
  4. Analysis of the cellular proto-oncogene mht/raf: relationship to the 5' sequences of v-mht in avian carcinoma virus MH2 and v-raf in murine sarcoma virus 3611. Flordellis CS, et al. Virology, 1985 Mar. PMID 3002017
  5. Nucleotide sequence analysis of the chicken gene c-mil, the progenitor of the retroviral oncogene v-mil. Jansen HW, et al. Virology, 1985 Jun. PMID 2998016

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAF kinase activity is essential to establish the balance between cell proliferation and death in neuroepithelial otic precursors, and for otic neuron differentiation and axonal growth at the acoustic-vestibular ganglion
    Title: RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.
  2. a complete map of the c-mil/raf-1 gene and a revision of the exon numbers
    Title: A revised and complete map of the chicken c-mil/raf-1 locus.
  3. Inducible gene deletion of the c-mil/raf-1 gene in chicken DT40 B cells revealed that, in addition to B-Raf, Raf-1 acts as an accessory ERK activator following engagement of the B cell antigen receptor.
    Title: Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
C-RAF
MIL proto-oncogene serine/threonine-protein kinase
c-mil protein
v-raf-1 murine leukemia viral oncogene homolog 1
NP_990638.1
XP_015148495.1
XP_015148496.1
XP_015148497.1
XP_015148498.1
XP_015148499.1
XP_025010214.1
XP_025010215.1
XP_040502065.1
XP_040502066.1
XP_040502067.1
XP_040502068.1
XP_040502069.1
XP_040502070.1
XP_046755784.1
XP_046755785.1
XP_046755786.1
XP_046755787.1
XP_046755788.1
XP_046782072.1
XP_046782073.1
XP_046782074.1
XP_046782075.1
XP_046782076.1
XP_046782077.1
XP_046782078.1
XP_046782079.1
XP_046782080.1
XP_046782081.1
XP_046782082.1
XP_046782083.1
XP_046782084.1
XP_046782085.1
XP_046782086.1
XP_046782087.1
XP_046782088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205307.2 → NP_990638.1  RAF proto-oncogene serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_990638.1

    Status: PROVISIONAL

    Source sequence(s)
    X07017
    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5135889..5204860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646131.2 → XP_040502065.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  2. XM_040646135.2 → XP_040502069.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    Conserved Domains (3) summary
    cd14149
    Location:303 → 585
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  3. XM_046899832.1 → XP_046755788.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A452J7W6

  4. XM_040646133.2 → XP_040502067.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_015293011.4 → XP_015148497.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    P05625
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  6. XM_046899828.1 → XP_046755784.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  7. XM_046899829.1 → XP_046755785.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  8. XM_046899831.1 → XP_046755787.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  9. XM_040646136.2 → XP_040502070.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    Conserved Domains (3) summary
    cd14149
    Location:303 → 585
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  10. XM_040646132.2 → XP_040502066.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  11. XM_015293010.4 → XP_015148496.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    P05625
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  12. XM_040646134.2 → XP_040502068.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A452J7W6
    Related
    ENSGALP00010041444.1, ENSGALT00010067701.1
    Conserved Domains (3) summary
    cd14149
    Location:323 → 605
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  13. XM_025154446.3 → XP_025010214.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  14. XM_015293012.4 → XP_015148498.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    P05625
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  15. XM_025154447.3 → XP_025010215.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    Conserved Domains (3) summary
    cd14149
    Location:303 → 585
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  16. XM_015293013.4 → XP_015148499.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894
    Related
    ENSGALP00010041446.1, ENSGALT00010067703.1
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  17. XM_015293009.4 → XP_015148495.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    P05625
    Related
    ENSGALP00010041443.1, ENSGALT00010067700.1
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  18. XM_046899830.1 → XP_046755786.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5160148..5229102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926123.1 → XP_046782079.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  2. XM_046926132.1 → XP_046782088.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

  3. XM_046926128.1 → XP_046782084.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A452J7W6

  4. XM_046926127.1 → XP_046782083.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894

  5. XM_046926118.1 → XP_046782074.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  6. XM_046926120.1 → XP_046782076.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  7. XM_046926122.1 → XP_046782078.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  8. XM_046926131.1 → XP_046782087.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

  9. XM_046926125.1 → XP_046782081.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894

  10. XM_046926119.1 → XP_046782075.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  11. XM_046926129.1 → XP_046782085.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A452J7W6

  12. XM_046926126.1 → XP_046782082.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894

  13. XM_046926117.1 → XP_046782073.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  14. XM_046926130.1 → XP_046782086.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

  15. XM_046926124.1 → XP_046782080.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/Swiss-Prot
    P05625, Q90893, Q90894

  16. XM_046926116.1 → XP_046782072.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

  17. XM_046926121.1 → XP_046782077.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05625.1 GenPept UniProtKB/Swiss-Prot:P05625

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