BRAF B-Raf proto-oncogene, serine/threonine kinase [Gallus gallus (chicken)] - Gene

Summary

Symbol: BRAFprovided by CGNC
Full Name: B-Raf proto-oncogene, serine/threonine kinaseprovided by CGNC
Primary source: CGNC:9744
See related: Ensembl:ENSGALG00010013466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: RMIL; C-RMIL
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (56964892..57047466, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (57265901..57348564, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRAF alternative splicing is differentially regulated in avian, rodent and primates. Exon 9b is present in vertebrates but exon 8b is present only in eutherians.
Title: B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse.
Neutralizing mutations of D447/8, S446 & S447, or uncoupling of B-Raf from Ras-GTP, reduce chicken B-Raf actvity in PC12 differentiation. S365 is a 14-3-3 binding site. B-Raf(V600E) cannot be inhibited by blocking S446 phosphorylation or Ras activation.
Title: Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein.
Inducible gene deletion of the c-Rmil/B-raf gene in chicken DT40 B cells revealed that B-Raf is required for the maintenance of basal ERK activity as well as for a rapid and sustained ERK activation following B cell antigen receptor (BCR) activation.
Title: Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase B-raf

Names: B-Raf proto-oncogene serine/threonine-protein kinase; proto-oncogene B-Raf; proto-oncogene c-Rmil; rmil serine/threonine-protein kinase; serine/threonine kinase; serine/threonine-protein kinase Rmil; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1

NP_001383911.1

EC 2.7.11.1

NP_001383912.1

EC 2.7.11.1

NP_001383913.1

EC 2.7.11.1

NP_990633.1

EC 2.7.11.1

XP_025002611.2

EC 2.7.11.1

XP_025002616.2

EC 2.7.11.1

XP_040521971.1

EC 2.7.11.1

XP_046762849.1

EC 2.7.11.1

XP_046762850.1

EC 2.7.11.1

XP_046762851.1

EC 2.7.11.1

XP_046762852.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396982.1 → NP_001383911.1 serine/threonine-protein kinase B-raf isoform 1

Status: VALIDATED

Source sequence(s)

JAENSK010000012

UniProtKB/Swiss-Prot

A0A1D5PGI2, Q04982, Q8AV85

UniProtKB/TrEMBL

A0A8V0YMN5

Related

ENSGALP00010019192.1, ENSGALT00010032437.1

Conserved Domains (3) summary

cd14062
Location:503 → 755

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001396983.1 → NP_001383912.1 serine/threonine-protein kinase B-raf isoform 3

Status: VALIDATED

Source sequence(s)

JAENSK010000012

UniProtKB/Swiss-Prot

A0A1D5PGI2, Q04982, Q8AV85

Conserved Domains (3) summary

cd14062
Location:463 → 715

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_001396984.1 → NP_001383913.1 serine/threonine-protein kinase B-raf isoform 4

Status: VALIDATED

Source sequence(s)

JAENSK010000012

UniProtKB/Swiss-Prot

A0A1D5PGI2, Q04982, Q8AV85

UniProtKB/TrEMBL

A0A8V0YSN1

Related

ENSGALP00010019195.1, ENSGALT00010032441.1

Conserved Domains (3) summary

cd14062
Location:463 → 715

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

cd20871
Location:230 → 289

C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
NM_205302.2 → NP_990633.1 serine/threonine-protein kinase B-raf isoform 2

See identical proteins and their annotated locations for NP_990633.1

Status: VALIDATED

Source sequence(s)

JAENSK010000012

UniProtKB/Swiss-Prot

A0A1D5PGI2, Q04982, Q8AV85

Related

ENSGALP00010019186.1, ENSGALT00010032426.1

Conserved Domains (4) summary

cd01816
Location:156 → 227

Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases

cd14062
Location:503 → 755

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

pfam00069
Location:498 → 753

Pkinase; Protein kinase domain

pfam00130
Location:235 → 280

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

56964892..57047466 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025146848.3 → XP_025002616.2 serine/threonine-protein kinase B-raf isoform X3

UniProtKB/Swiss-Prot

A0A1D5PGI2, Q04982, Q8AV85

Conserved Domains (3) summary

smart00109
Location:235 → 280

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cd14062
Location:505 → 757

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
XM_025146843.3 → XP_025002611.2 serine/threonine-protein kinase B-raf isoform X2

UniProtKB/Swiss-Prot

A0A1D5PGI2, Q04982, Q8AV85

Conserved Domains (3) summary

smart00109
Location:235 → 280

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cd14062
Location:505 → 757

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
XM_040666037.2 → XP_040521971.1 serine/threonine-protein kinase B-raf isoform X1

UniProtKB/Swiss-Prot

A0A1D5PGI2, Q04982, Q8AV85

Conserved Domains (3) summary

smart00109
Location:235 → 280

C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

cd14062
Location:545 → 797

STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases

cd17134
Location:154 → 232

RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

57265901..57348564 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046906895.1 → XP_046762851.1 serine/threonine-protein kinase B-raf isoform X3
XM_046906894.1 → XP_046762850.1 serine/threonine-protein kinase B-raf isoform X2
XM_046906893.1 → XP_046762849.1 serine/threonine-protein kinase B-raf isoform X1
XM_046906896.1 → XP_046762852.1 serine/threonine-protein kinase B-raf isoform X4