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HRAS HRas proto-oncogene, GTPase [ Gallus gallus (chicken) ]

Gene ID: 396229, updated on 5-Mar-2024

Summary

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Symbol
HRASprovided by CGNC
Full Name
HRas proto-oncogene, GTPaseprovided by CGNC
Primary source
CGNC:5197
See related
Ensembl:ENSGALG00010025590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
H-RAS; HRAS1; p21ras; H-Ras-1; c-H-ras
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (15587152..15641067)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (15561453..15615386)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110943 Neighboring gene leucine rich repeat containing 56 Neighboring gene USP6 N-terminal like Neighboring gene transfer RNA alanine (anticodon AGC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a provirally activated c-Ha-ras oncogene in an avian nephroblastoma via a novel procedure: cDNA cloning of a chimaeric viral-host transcript. Westaway D, et al. EMBO J, 1986 Feb. PMID 3011401, Free PMC Article
  2. HRAS, EGFR, MET, and RON Genes Are Recurrently Activated by Provirus Insertion in Liver Tumors Induced by the Retrovirus Myeloblastosis-Associated Virus 2. Pecenka V, et al. J Virol, 2017 Oct 15. PMID 28768863, Free PMC Article
  3. BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. Imamura Y, et al. J Biol Chem, 2009 Apr 10. PMID 19218240, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GDP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
GTPase HRas
Names
Harvey rat sarcoma viral oncogene homolog
transforming protein p21
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
v-Ha-ras Harvey rat sarcoma viral oncogene-like protein
NP_001383675.1
NP_001383676.1
NP_001383677.1
NP_990623.1
XP_046773855.1
XP_046773856.1
XP_046773857.1
XP_046773858.1
XP_046773859.1
XP_046797430.1
XP_046797431.1
XP_046797432.1
XP_046797433.1
XP_046797434.1
XP_046797435.1
XP_046797436.1
XP_046797437.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396746.1 → NP_001383675.1  GTPase HRas

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000214
    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  2. NM_001396747.1 → NP_001383676.1  GTPase HRas

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000214
    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  3. NM_001396748.1 → NP_001383677.1  GTPase HRas

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000214
    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

  4. NM_205292.2 → NP_990623.1  GTPase HRas

    See identical proteins and their annotated locations for NP_990623.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000214
    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1
    Conserved Domains (1) summary
    cd04138
    Location:3 → 164
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15587152..15641067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046941474.1 → XP_046797430.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  2. XM_046941476.1 → XP_046797432.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  3. XM_046941477.1 → XP_046797433.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  4. XM_046941479.1 → XP_046797435.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  5. XM_046941480.1 → XP_046797436.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  6. XM_046941478.1 → XP_046797434.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  7. XM_046941481.1 → XP_046797437.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  8. XM_046941475.1 → XP_046797431.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1
    Related
    ENSGALP00010038607.1, ENSGALT00010062441.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15561453..15615386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917901.1 → XP_046773857.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  2. XM_046917899.1 → XP_046773855.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  3. XM_046917900.1 → XP_046773856.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  4. XM_046917902.1 → XP_046773858.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1

  5. XM_046917903.1 → XP_046773859.1  GTPase HRas isoform X1

    UniProtKB/Swiss-Prot
    P08642
    UniProtKB/TrEMBL
    F5ANT1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08642.1 GenPept UniProtKB/Swiss-Prot:P08642

Gene LinkOut

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