HSPB1 heat shock protein family B (small) member 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: HSPB1provided by CGNC
Official Full Name: heat shock protein family B (small) member 1provided by CGNC
Primary source: CGNC:1361
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: hsp25; cHsp25
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	19	NC_052550.1 (4741288..4743195, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	19	NC_052591.1 (4469667..4471574, complement)

Chromosome 19 - NC_052550.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASA pre-treatment induced a level of HspB1 presumed to be sufficient to protect myocardial cells from acute heat stress in the extracorporal model, although more detailed mechanisms will require further investigation
Title: In vitro evaluation of aspirin-induced HspB1 against heat stress damage in chicken myocardial cells.
These results suggest that HSPB1 protein forms complexes with alphaB-crystallin in aged chicken muscle and suppose to become the candidate of age-related bio-marker for verifying the age of chicken meat.
Title: Chicken heat shock protein HSPB1 increases and interacts with αB-crystallin in aged skeletal muscle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein refolding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to heat	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heat shock protein beta-1

Names: 25 kDa IAP; 25-kD IAP; HSP 25; HSP 27; actin polymerization inhibitor; heat shock 25 kDa protein; heat shock 27 kDa protein; heat shock 27kDa protein 1; heat shock protein B1; inhibitor of actin polymerization

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205290.2 → NP_990621.2 heat shock protein beta-1

Status: VALIDATED

Source sequence(s)

JAENSK010000323

UniProtKB/Swiss-Prot

Q00649

Conserved Domains (1) summary

cd06475
Location:83 → 168

ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

4741288..4743195 complement

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GenBank, FASTA, Sequence Viewer (Graphics)