CCN3 cellular communication network factor 3 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CCN3provided by CGNC
Official Full Name: cellular communication network factor 3provided by CGNC
Primary source: CGNC:49699
See related: Ensembl:ENSGALG00010009284
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: NOV
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (135485666..135490964)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (135693497..135698789)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of NOV was intense in the developing tendons and in the developing joints, whereas the chondrogenic blastemas were negative for NOV transcripts. NOV induced intense upregulation of Tenascin C and, at a reduced level, of alpha 5 Integrin, Sox9, and Activin beta-A.
Title: Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.
Results establish the expression pattern of CCN3 in the developing retina, and show CCN3 expression is induced by activated BMP signaling, whereas Notch signaling decreases CCN3 mRNA and protein levels in Muller cells and has no effect in retinal neurons.
Title: Temporal and spatial expression of CCN3 during retina development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CCN family member 3

Names: nephroblastoma overexpressed; nephroblastoma-overexpressed gene protein; protein NOV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205268.2 → NP_990599.2 CCN family member 3 precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000044

UniProtKB/Swiss-Prot

P28686

UniProtKB/TrEMBL

A0A1D5P2P1

Related

ENSGALP00010012681.1, ENSGALT00010022108.1

Conserved Domains (4) summary

smart00121
Location:31 → 99

IB; Insulin growth factor-binding protein homologues

smart00041
Location:263 → 332

CT; C-terminal cystine knot-like domain (CTCK)

smart00209
Location:205 → 246

TSP1; Thrombospondin type 1 repeats

smart00214
Location:106 → 166

VWC; von Willebrand factor (vWF) type C domain