E2F1 E2F transcription factor 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: E2F1provided by CGNC
Full Name: E2F transcription factor 1provided by CGNC
Primary source: CGNC:2206
See related: Ensembl:ENSGALG00010022055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	20	NC_052551.1 (2516140..2519952)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	20	NC_052592.1 (2286404..2290216)

Chromosome 20 - NC_052551.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E2F1 can bind directly to promoters of the miR-17~92 and miR-106a~363 clusters and activate their transcription, and E2F1 protein expression is correlated with the expression of pri-miR-17~92 and pri-miR-106a~363 during myoblast differentiation.
Title: E2F1-miR-20a-5p/20b-5p auto-regulatory feedback loop involved in myoblast proliferation and differentiation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of Rb-E2F complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transcription factor E2F1

Names: E2F-1 transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205219.2 → NP_990550.2 transcription factor E2F1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000328

UniProtKB/Swiss-Prot

Q90977

Related

ENSGALP00010032308.1, ENSGALT00010053627.1

Conserved Domains (1) summary

cd14660
Location:178 → 278

E2F_DD; Dimerization domain of E2F transcription factors

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052551.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2516140..2519952

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015296338.4 → XP_015151824.1 transcription factor E2F1 isoform X1

UniProtKB/Swiss-Prot

Q90977

Conserved Domains (2) summary

cd14660
Location:178 → 278

E2F_DD; Dimerization domain of E2F transcription factors

pfam02319
Location:106 → 169

E2F_TDP; E2F/DP family winged-helix DNA-binding domain