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FN1 fibronectin 1 [ Gallus gallus (chicken) ]

Gene ID: 396133, updated on 3-Apr-2024

Summary

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Official Symbol
FN1provided by CGNC
Official Full Name
fibronectin 1provided by CGNC
Primary source
CGNC:2613
See related
Ensembl:ENSGALG00010011984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
FN
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
47
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (4440758..4490944, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (4382075..4432210, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 12 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC112532769 Neighboring gene uncharacterized LOC121111289

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain. Stettler EM, et al. J Comp Neurol, 2004 Jan 12. PMID 14681936
  2. Suppression of cell adhesion and spreading activities of fibronectin by arginine-specific ADP-ribosyltransferase from chicken polymorphonuclear leukocytes. Terashima M, et al. Biochim Biophys Acta, 1998 Sep 16. PMID 9739157
  3. A highly conserved region upstream of the fibronectin alternative exon EIIIA 3' splice site interacts with cell-type-specific nuclear proteins. Norton PA, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473640
  4. The exon encoding the fibronectin type III-9 repeat is constitutively included in the mRNA from chick limb mesenchyme and cartilage. Gehris AL, et al. Biochim Biophys Acta, 1996 Mar 27. PMID 8603103
  5. Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Mayer BW Jr, et al. Dev Biol, 1981 Mar. PMID 7014292

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
    Title: Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis.
  2. Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
    Title: Fibronectin assembly during early embryo development: A versatile communication system between cells and tissues.
  3. cell rearrangements guided by a fibronectin matrix have a role in somitogenesis
    Title: Dynamic 3D cell rearrangements guided by a fibronectin matrix underlie somitogenesis.
  4. We provide a hypothesis whereby a combination of activated surface integrin levels and the degree to which those receptors are clustered determines NCC motility on fibronectin.
    Title: Neural crest motility on fibronectin is regulated by integrin activation.
  5. fibronectin is produced by radial glia and is aligned along their surfaces before and during migration
    Title: Radial glia produce and align the ligand fibronectin during neuronal migration in the developing chick brain.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-substrate junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibronectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198712.2 → NP_001185641.1  fibronectin precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000235
    UniProtKB/Swiss-Prot
    F1NJT3, P11722, Q90921
    UniProtKB/TrEMBL
    A0A8V0YC34
    Related
    ENSGALP00010016500.1, ENSGALT00010028696.1
    Conserved Domains (6) summary
    smart00059
    Location:418 → 466
    FN2; Fibronectin type 2 domain
    smart00058
    Location:188 → 232
    FN1; Fibronectin type 1 domain
    cd00061
    Location:53 → 91
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:2000 → 2080
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:2302 → 2341
    fn1; Fibronectin type I domain
    pfam00041
    Location:1544 → 1625
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4440758..4490944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046943492.1 → XP_046799448.1  fibronectin isoform X6

    Related
    ENSGALP00010016522.1, ENSGALT00010028720.1

  2. XM_046943491.1 → XP_046799447.1  fibronectin isoform X3

  3. XM_015289128.4 → XP_015144614.1  fibronectin isoform X1

    UniProtKB/TrEMBL
    A0A8V0YC34
    Conserved Domains (6) summary
    smart00059
    Location:418 → 466
    FN2; Fibronectin type 2 domain
    smart00058
    Location:188 → 232
    FN1; Fibronectin type 1 domain
    cd00061
    Location:53 → 91
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:2000 → 2080
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:2302 → 2341
    fn1; Fibronectin type I domain
    pfam00041
    Location:1544 → 1625
    fn3; Fibronectin type III domain

  4. XM_015289133.4 → XP_015144619.1  fibronectin isoform X8

    UniProtKB/TrEMBL
    A0A8V0YC34
    Conserved Domains (6) summary
    smart00059
    Location:418 → 466
    FN2; Fibronectin type 2 domain
    smart00058
    Location:188 → 232
    FN1; Fibronectin type 1 domain
    cd00061
    Location:53 → 91
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1819 → 1899
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:2121 → 2160
    fn1; Fibronectin type I domain
    pfam00041
    Location:1453 → 1534
    fn3; Fibronectin type III domain

  5. XM_015289132.4 → XP_015144618.1  fibronectin isoform X5

    UniProtKB/TrEMBL
    A0A8V0YC34, A0A8V0YDD6
    Related
    ENSGALP00010016514.1, ENSGALT00010028712.1
    Conserved Domains (6) summary
    smart00059
    Location:418 → 466
    FN2; Fibronectin type 2 domain
    smart00058
    Location:188 → 232
    FN1; Fibronectin type 1 domain
    cd00061
    Location:53 → 91
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1909 → 1989
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:2211 → 2250
    fn1; Fibronectin type I domain
    pfam00041
    Location:1453 → 1534
    fn3; Fibronectin type III domain

  6. XM_046943493.1 → XP_046799449.1  fibronectin isoform X7

  7. XM_015289131.4 → XP_015144617.1  fibronectin isoform X4

    UniProtKB/TrEMBL
    A0A8V0YC34, A0A8V0YFJ8
    Related
    ENSGALP00010016505.1, ENSGALT00010028702.1
    Conserved Domains (6) summary
    smart00059
    Location:418 → 466
    FN2; Fibronectin type 2 domain
    smart00058
    Location:188 → 232
    FN1; Fibronectin type 1 domain
    cd00061
    Location:53 → 91
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:1910 → 1990
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:2212 → 2251
    fn1; Fibronectin type I domain
    pfam00041
    Location:1544 → 1625
    fn3; Fibronectin type III domain

  8. XM_015289129.4 → XP_015144615.1  fibronectin isoform X2

    UniProtKB/TrEMBL
    A0A8V0YC34
    Conserved Domains (6) summary
    smart00059
    Location:418 → 466
    FN2; Fibronectin type 2 domain
    smart00058
    Location:188 → 232
    FN1; Fibronectin type 1 domain
    cd00061
    Location:53 → 91
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00063
    Location:2000 → 2080
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00039
    Location:2258 → 2297
    fn1; Fibronectin type I domain
    pfam00041
    Location:1544 → 1625
    fn3; Fibronectin type III domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4382075..4432210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921137.1 → XP_046777093.1  fibronectin isoform X6

  2. XM_046921134.1 → XP_046777090.1  fibronectin isoform X3

  3. XM_046921132.1 → XP_046777088.1  fibronectin isoform X1

  4. XM_046921139.1 → XP_046777095.1  fibronectin isoform X8

  5. XM_046921136.1 → XP_046777092.1  fibronectin isoform X5

    UniProtKB/TrEMBL
    A0A8V0YDD6

  6. XM_046921138.1 → XP_046777094.1  fibronectin isoform X7

  7. XM_046921135.1 → XP_046777091.1  fibronectin isoform X4

    UniProtKB/TrEMBL
    A0A8V0YFJ8

  8. XM_046921133.1 → XP_046777089.1  fibronectin isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11722.4 GenPept UniProtKB/Swiss-Prot:P11722

Gene LinkOut

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