SOX2 SRY-box 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SOX2provided by CGNC
Full Name: SRY-box 2provided by CGNC
Primary source: CGNC:49650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	9	NC_052540.1 (16567995..16570458, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	9	NC_052581.1 (16360134..16362594, complement)

Chromosome 9 - NC_052540.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A gradient of Wnt activity positions the neurosensory domains of the inner ear.
Title: A gradient of Wnt activity positions the neurosensory domains of the inner ear.
Neural-fated self-renewing cells regulated by Sox2 during secondary neurulation in chicken tail bud.
Title: Neural-fated self-renewing cells regulated by Sox2 during secondary neurulation in chicken tail bud.
SNP g.32828A>G of RB1 is an obesity-associated variant that directly affects binding with NF-KB and SOX2, leading to changes in RB1 expression which in turn may influence chicken abdominal fat deposition.
Title: Functional Intronic Variant in the Retinoblastoma 1 Gene Underlies Broiler Chicken Adiposity by Altering Nuclear Factor-kB and SRY-Related HMG Box Protein 2 Binding Sites.
Sox2 participates in the regulation of Cped1.
Title: Cped1 promotes chicken SSCs formation with the aid of histone acetylation and transcription factor Sox2.
Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage.
Title: Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation.
Data obtained in this study deciphers a novel role of hindbrain boundaries as repetitive pools of neural stem/progenitor cells, which provide proliferating progenitors and differentiating neurons in a Sox2-dependent regulation.
Title: A new role of hindbrain boundaries as pools of neural stem/progenitor cells regulated by Sox2.
Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system.
Title: Positive feedback loop between Sox2 and Sox6 inhibits neuronal differentiation in the developing central nervous system.
Data indicate that cultured embryonic stem cells (cESCs) expressed pluripotency transcription factors, POUV, Sox-2, Nanog and Lin28 exhibited typical characteristics of pluripotency, even after six generations of rapid doubling.
Title: Four recombinant pluripotency transcriptional factors containing a protein transduction domain maintained the in vitro pluripotency of chicken embryonic stem cells.
The results of this study suggested that high levels of Sox2 inhibit progression of neurogenesis in the developing inner ear
Title: Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by neurogenin1 and neurod1.
Sensory competence is established early in otic development through the activation of Atoh1 by Sox2, however, hair cell differentiation is prevented until later stages by the parallel activation of negative regulators of Atoh1 function.
Title: The prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transcription factor SOX-2

Names: SRY (sex determining region Y)-box 2; Sox2 transcription factor; cSox2; delta EF2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205188.3 → NP_990519.3 transcription factor SOX-2

Status: VALIDATED

Source sequence(s)

JAENSK010000240

UniProtKB/Swiss-Prot

P48430, Q54A48

UniProtKB/TrEMBL

A0A8V0YYM3

Conserved Domains (2) summary

cd01388
Location:38 → 109

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam12336
Location:108 → 198

SOXp; SOX transcription factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

16567995..16570458 complement

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Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

16360134..16362594 complement

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GenBank, FASTA, Sequence Viewer (Graphics)