ESR1 estrogen receptor 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: ESR1provided by CGNC
Full Name: estrogen receptor 1provided by CGNC
Primary source: CGNC:9821
See related: Ensembl:ENSGALG00010005186
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (48719758..48824554)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (48622684..48727452)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic changes associated with increased estrogen receptor alpha mRNA transcript abundance during reproductive maturation in chicken ovaries.
Title: Epigenetic changes associated with increased estrogen receptor alpha mRNA transcript abundance during reproductive maturation in chicken ovaries.
differential expression of ER-alpha may contribute to regulate the reproductive function in the mature chicken or the cessation of reproductive function in aged chickens
Title: Changes in the immunohistochemical localization of estrogen receptor alpha and in the stereological parameters of the testes of mature and aged chickens (Gallus domesticus).
The variations of ESR1 or PR expression or dominance of either PR expression is differentially regulated depending on the cell type in the chicken oviduct.
Title: Immunohistochemical localization of progesterone receptor isoforms and estrogen receptor alpha in the chicken oviduct magnum during development.
differential expression of ER-alpha in both chicken ovaries during development in a cell type-specific distribution, suggesting that these differences may be regarded as an important cause in the process of asymmetric ovarian development in the chicken
Title: Changes in the cellular localization of estrogen receptor alpha in the growing and regressing ovaries of Gallus domesticus during development.
Data show that hepatocellular carcinoma LMH cells transfected with a reporter construct bearing the vitellogenin promoter is a useful model for the study of hydrocarbon receptor (AHR)-estrogen receptor (ER) interaction in liver-derived cells.
Title: Aryl hydrocarbon receptor activation leads to impairment of estrogen-driven chicken vitellogenin promoter activity in LMH cells.
There were no significant differences in ERalpha mRNA expression during stress induced by fasting and refeeding.
Title: Changes in estrogen receptor ERalpha and ERbeta expression in chicken (Gallus domesticus) adrenal gland during short-fasting and refeeding.
cell-specific distribution of ERalpha and AR in the anterior pituitary from adult cockerels by immunohistochemistry
Title: Cell-specific distributions of estrogen receptor alpha (ERα) and androgen receptor (AR) in anterior pituitary glands from adult cockerels as revealed by immunohistochemistry.
Data show that estrogen receptor 1 mRNA is over-expressed in early-stage tumors, suggesting that expression of the oviduct-related genes may be regulated by estrogen.
Title: Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?
ERalpha plays an important role in sex differentiation of the reproductive tract in female chicken embryos and can mediate xenoestrogen-induced disturbances of sex differentiation.
Title: Activation of estrogen receptor alpha disrupts differentiation of the reproductive organs in chicken embryos.
immunohistochemical (IHC) localization of oestrogen receptor alpha was studied in the developing left ovary of 14.5-day-old chick embryos; intracellular localization was cytoplasmic, nuclear, or both
Title: Immunohistochemical localization of oestrogen receptor alpha in the various cell categories of chick embryo ovary.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in steroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: estrogen receptor

Names: ER; ER-alpha; estradiol receptor; estrogen receptor, alpha; nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205183.2 → NP_990514.1 estrogen receptor

See identical proteins and their annotated locations for NP_990514.1

Status: PROVISIONAL

Source sequence(s)

X03805

UniProtKB/Swiss-Prot

P06212

UniProtKB/TrEMBL

E5L8C9

Related

ENSGALP00010006834.1, ENSGALT00010012244.1

Conserved Domains (4) summary

cd06949
Location:304 → 541

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:174 → 255

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 175

Oest_recep; Oestrogen receptor

pfam12743
Location:550 → 589

ESR1_C; Oestrogen-type nuclear receptor final C-terminal