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NFKB1 nuclear factor kappa B subunit 1 [ Gallus gallus (chicken) ]

Gene ID: 396033, updated on 3-Apr-2024

Summary

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Symbol
NFKB1provided by CGNC
Full Name
nuclear factor kappa B subunit 1provided by CGNC
Primary source
CGNC:49618
See related
Ensembl:ENSGALG00010005476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
NF-KB1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
26
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (60304611..60362176)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (60301648..60359234)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene B-cell scaffold protein with ankyrin repeats 1 Neighboring gene uncharacterized LOC121110727 Neighboring gene solute carrier family 39 member 8 Neighboring gene uncharacterized LOC121110726 Neighboring gene mannosidase beta Neighboring gene ubiquitin conjugating enzyme E2 D3 Neighboring gene solute carrier family 9 member B2 Neighboring gene CDGSH iron sulfur domain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional and post-transcriptional regulation of kappaB-controlled genes by pp60v-src. Cabannes E, et al. Oncogene, 1997 Jul 3. PMID 9233775
  2. p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells. Capobianco AJ, et al. J Virol, 1992 Jun. PMID 1533881, Free PMC Article
  3. The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells. James J, et al. J Gen Virol, 2019 Mar. PMID 30672726
  4. Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1. Ge C, et al. Biol Reprod, 2009 Mar. PMID 19005168
  5. Isolation of the chicken NF-kappa B p65 subunit-encoding cDNA and characterization of its products. Ikeda T, et al. Gene, 1993 Nov 15. PMID 7916720

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial localization of PB1-F2 resulted in reduced antagonism of an NFkappaB-dependent promoter.
    Title: The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells.
  2. SNP g.32828A>G of RB1 is an obesity-associated variant that directly affects binding with NF-KB and SOX2, leading to changes in RB1 expression which in turn may influence chicken abdominal fat deposition.
    Title: Functional Intronic Variant in the Retinoblastoma 1 Gene Underlies Broiler Chicken Adiposity by Altering Nuclear Factor-kB and SRY-Related HMG Box Protein 2 Binding Sites.
  3. RNA sequencing results revealed that the chicken NFKB1 was differently expressed between the intestinal mucosal layer of Necrotic enteritis induced chicken lines that are resistant and sensitive to avian leukosis and Marek's disease.
    Title: Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken.
  4. EGF stimulated proliferation of chicken PGCs via activation of Ca(2+)/PKC involving NFKB1 signaling pathway.
    Title: Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor NF-kappa-B p105 subunit
Names
NF-kB p50 subunit
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396395.1 → NP_001383324.1  nuclear factor NF-kappa-B p105 subunit isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/TrEMBL
    A0A8V0XLT0, A0A8V0XLT5
    Related
    ENSGALP00010007652.1, ENSGALT00010013090.1
    Conserved Domains (5) summary
    cd07935
    Location:47 → 248
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd01177
    Location:255 → 356
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:815 → 890
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:540 → 577
    ANK; ANK repeat [structural motif]
    cl39094
    Location:514 → 725
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001396396.1 → NP_001383325.1  nuclear factor NF-kappa-B p105 subunit isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/TrEMBL
    A0A8V0XLT0
    Conserved Domains (5) summary
    cd07935
    Location:46 → 247
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd01177
    Location:254 → 355
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:814 → 889
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:539 → 576
    ANK; ANK repeat [structural motif]
    cl39094
    Location:513 → 724
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_205134.2 → NP_990465.2  nuclear factor NF-kappa-B p105 subunit isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000074
    UniProtKB/TrEMBL
    A0A8V0XLT0, A0A8V0XLT5
    Conserved Domains (5) summary
    cd07935
    Location:47 → 248
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd01177
    Location:255 → 356
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:815 → 890
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:540 → 577
    ANK; ANK repeat [structural motif]
    cl39094
    Location:514 → 725
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    60304611..60362176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046939919.1 → XP_046795875.1  nuclear factor NF-kappa-B p105 subunit isoform X3

  2. XM_046939920.1 → XP_046795876.1  nuclear factor NF-kappa-B p105 subunit isoform X4

  3. XM_015285417.4 → XP_015140903.2  nuclear factor NF-kappa-B p105 subunit isoform X2

    UniProtKB/TrEMBL
    A0A8V0XLT0
    Conserved Domains (5) summary
    cd07935
    Location:46 → 247
    RHD-n_NFkB1; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa B1 (NF-kappa B1)
    cd01177
    Location:254 → 355
    IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    cd08797
    Location:814 → 889
    Death_NFkB1_p105; Death domain of the Nuclear Factor-KappaB1 precursor protein p105
    sd00045
    Location:539 → 576
    ANK; ANK repeat [structural motif]
    cl39094
    Location:513 → 724
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_046939918.1 → XP_046795874.1  nuclear factor NF-kappa-B p105 subunit isoform X1

    UniProtKB/TrEMBL
    A0A8V0XLT5
    Related
    ENSGALP00010007637.1, ENSGALT00010013075.1

  5. XM_046939917.1 → XP_046795873.1  nuclear factor NF-kappa-B p105 subunit isoform X1

    UniProtKB/TrEMBL
    A0A8V0XLT5

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    60301648..60359234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915553.1 → XP_046771509.1  nuclear factor NF-kappa-B p105 subunit isoform X1

  2. XM_046915552.1 → XP_046771508.1  nuclear factor NF-kappa-B p105 subunit isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04861.2 GenPept UniProtKB/Swiss-Prot:Q04861

Gene LinkOut

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