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PPP1R12A protein phosphatase 1 regulatory subunit 12A [ Gallus gallus (chicken) ]

Gene ID: 396020, updated on 3-Apr-2024

Summary

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Official Symbol
PPP1R12Aprovided by CGNC
Official Full Name
protein phosphatase 1 regulatory subunit 12Aprovided by CGNC
Primary source
CGNC:49610
See related
Ensembl:ENSGALG00010013333
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
MBS; MBSP; MYPT1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
29
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (39654566..39778848, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (39997704..40121991, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin 1 Neighboring gene uncharacterized LOC121109500 Neighboring gene pro-apoptotic WT1 regulator Neighboring gene uncharacterized LOC101749704 Neighboring gene ribosomal protein S16 Neighboring gene otogelin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells. Murányi A, et al. FEBS Lett, 2005 Dec 5. PMID 16297917
  2. Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase. Shimizu H, et al. J Biol Chem, 1994 Dec 2. PMID 7982954
  3. Structural basis of protein phosphatase 1 regulation. Terrak M, et al. Nature, 2004 Jun 17. PMID 15164081
  4. Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M. Chen YH, et al. FEBS Lett, 1994 Dec 12. PMID 7988720
  5. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of myosin-light-chain-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in A band IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 12A
Names
130 kDa myosin-binding subunit of smooth muscle myosin phophatase
130 kDa myosin-binding subunit of smooth muscle myosin phosphatase
133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133)
PP1M subunit M110
myosin phosphatase target subunit 1
myosin phosphatase-targeting subunit 1
protein phosphatase 1, regulatory (inhibitor) subunit 12A
protein phosphatase myosin-binding subunit
smooth muscle myosin phosphatase myosin-binding subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205123.2 → NP_990454.1  protein phosphatase 1 regulatory subunit 12A

    See identical proteins and their annotated locations for NP_990454.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000012
    UniProtKB/Swiss-Prot
    Q10727, Q90623, Q90624
    UniProtKB/TrEMBL
    A0A8V0YJZ2
    Related
    ENSGALP00010018921.1, ENSGALT00010032131.1
    Conserved Domains (5) summary
    PHA03095
    Location:43 → 272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:930 → 984
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd21944
    Location:657 → 713
    IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    39654566..39778848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015278124.4 → XP_015133610.1  protein phosphatase 1 regulatory subunit 12A isoform X2

    UniProtKB/TrEMBL
    A0A8V0YK06
    Related
    ENSGALP00010018903.1, ENSGALT00010032113.1
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:930 → 1028
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

  2. XM_015278355.4 → XP_015133841.1  protein phosphatase 1 regulatory subunit 12A isoform X7

    UniProtKB/TrEMBL
    A0A8V0YK06
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:889 → 943
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

  3. XM_015278262.4 → XP_015133748.1  protein phosphatase 1 regulatory subunit 12A isoform X5

    UniProtKB/TrEMBL
    A0A8V0YJZ2
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:930 → 984
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

  4. XM_015278397.4 → XP_015133883.1  protein phosphatase 1 regulatory subunit 12A isoform X10

    UniProtKB/TrEMBL
    A0A8V0YJY2
    Conserved Domains (5) summary
    cd00204
    Location:72 → 167
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10 → 116
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:86 → 139
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:817 → 921
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:85 → 116
    ANK; ANK repeat [structural motif]

  5. XM_040657836.2 → XP_040513770.1  protein phosphatase 1 regulatory subunit 12A isoform X9

    UniProtKB/TrEMBL
    A0A1D5PPA0
    Conserved Domains (3) summary
    PHA03095
    Location:43 → 272
    PHA03095; ankyrin-like protein; Provisional
    PRK11448
    Location:843 → 925
    hsdR; type I restriction enzyme EcoKI subunit R; Provisional
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

  6. XM_015278203.4 → XP_015133689.1  protein phosphatase 1 regulatory subunit 12A isoform X3

    UniProtKB/TrEMBL
    A0A8V0YK06
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:889 → 993
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

  7. XM_015278309.4 → XP_015133795.1  protein phosphatase 1 regulatory subunit 12A isoform X6

    UniProtKB/TrEMBL
    A0A1D5PPA0
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:871 → 975
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

  8. XM_015278088.4 → XP_015133574.1  protein phosphatase 1 regulatory subunit 12A isoform X1

    UniProtKB/TrEMBL
    F1NA71
    Related
    ENSGALP00010018899.1, ENSGALT00010032109.1
    Conserved Domains (4) summary
    cd00204
    Location:67 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:930 → 1034
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]

  9. XM_040657656.2 → XP_040513590.1  protein phosphatase 1 regulatory subunit 12A isoform X8

    UniProtKB/TrEMBL
    A0A8V0YJY2

  10. XM_040657746.2 → XP_040513680.1  protein phosphatase 1 regulatory subunit 12A isoform X8

    UniProtKB/TrEMBL
    A0A8V0YJY2

  11. XM_040657382.2 → XP_040513316.1  protein phosphatase 1 regulatory subunit 12A isoform X4

    UniProtKB/Swiss-Prot
    Q10727, Q90623, Q90624
    UniProtKB/TrEMBL
    A0A8V0YJZ2
    Related
    ENSGALP00010018892.1, ENSGALT00010032102.1
    Conserved Domains (5) summary
    PHA03095
    Location:43 → 272
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:72 → 103
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:47 → 136
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:930 → 984
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cd21944
    Location:657 → 713
    IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    39997704..40121991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906764.1 → XP_046762720.1  protein phosphatase 1 regulatory subunit 12A isoform X2

  2. XM_046906770.1 → XP_046762726.1  protein phosphatase 1 regulatory subunit 12A isoform X7

  3. XM_046906767.1 → XP_046762723.1  protein phosphatase 1 regulatory subunit 12A isoform X5

  4. XM_046906774.1 → XP_046762730.1  protein phosphatase 1 regulatory subunit 12A isoform X10

  5. XM_046906773.1 → XP_046762729.1  protein phosphatase 1 regulatory subunit 12A isoform X9

  6. XM_046906765.1 → XP_046762721.1  protein phosphatase 1 regulatory subunit 12A isoform X3

  7. XM_046906769.1 → XP_046762725.1  protein phosphatase 1 regulatory subunit 12A isoform X6

  8. XM_046906763.1 → XP_046762719.1  protein phosphatase 1 regulatory subunit 12A isoform X1

  9. XM_046906771.1 → XP_046762727.1  protein phosphatase 1 regulatory subunit 12A isoform X8

  10. XM_046906772.1 → XP_046762728.1  protein phosphatase 1 regulatory subunit 12A isoform X8

  11. XM_046906766.1 → XP_046762722.1  protein phosphatase 1 regulatory subunit 12A isoform X4

    UniProtKB/Swiss-Prot
    Q10727, Q90623, Q90624
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90623.1 GenPept UniProtKB/Swiss-Prot:Q90623

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