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CTNNB1 catenin beta 1 [ Gallus gallus (chicken) ]

Gene ID: 395964, updated on 3-Apr-2024

Summary

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Official Symbol
CTNNB1provided by CGNC
Official Full Name
catenin beta 1provided by CGNC
Primary source
CGNC:49578
See related
Ensembl:ENSGALG00010016258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CHBCAT
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (43356658..43378265)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (43407464..43429101)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110088 Neighboring gene uncharacterized LOC107052525 Neighboring gene unc-51 like kinase 4 Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene trafficking kinesin protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hormonal regulation of beta-catenin during development of the avian oviduct and its expression in epithelial cell-derived ovarian carcinogenesis. Bae SM, et al. Mol Cell Endocrinol, 2014 Jan 25. PMID 24055276
  2. Sex-specific expression of CTNNB1 in the gonadal morphogenesis of the chicken. Bae SM, et al. Reprod Biol Endocrinol, 2013 Sep 11. PMID 24025394, Free PMC Article
  3. Identification of responsive cells in the developing somite supports a role for beta-catenin-dependent Wnt signaling in maintaining the DML myogenic progenitor pool. Brauner I, et al. Dev Dyn, 2010 Jan. PMID 19795517
  4. Isolation and characterization of chicken beta-catenin. Lu J, et al. Gene, 1997 Sep 1. PMID 9322759
  5. β-Catenin stabilization promotes proliferation and increase in cardiomyocyte number in chick embryonic epicardial explant culture. Polley A, et al. In Vitro Cell Dev Biol Anim, 2017 Dec. PMID 28842809

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we demonstrate that the balance of Ecad and Ncad is dependent upon the availability of beta-catenin proteins, and that alteration of either classical cadherin modifies the proportions of the neural crest and neuroectodermal cells that are specified
    Title: A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices.
  2. Beta-catenin role in the cardiomyocyte differentiation during chick cardiogenesis.
    Title: β-Catenin stabilization promotes proliferation and increase in cardiomyocyte number in chick embryonic epicardial explant culture.
  3. Cytoplasmic NOTCH and membrane-derived beta-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.
    Title: Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.
  4. We show that b-catenin is expressed during the pre-patterning of the epithelium prior to papilla induction and second that b-catenin, Ednrb and Inhba are expressed during the induction and patterning of the conjunctival papillae. Furthermore, we identified two genes, b-catenin and Prox1, that may be involved in the induction of the underlying scleral bones
    Title: Gene expression analysis during the induction and patterning of the conjunctival papillae in the chick embryonic eye.
  5. beta-catenin controls the cell fate and polarity of the neuroblasts through the expression and localization of aPKC.
    Title: Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole.
  6. CTNNB1 is present in gonads of both sexes during embryonic development and it may play essential roles in differentiation of Sertoli cells during formation of seminiferous tubules during development of the testes.
    Title: Sex-specific expression of CTNNB1 in the gonadal morphogenesis of the chicken.
  7. CTNNB1 is a novel gene regulated by estrogen in epithelial cells of the chicken oviduct.
    Title: Hormonal regulation of beta-catenin during development of the avian oviduct and its expression in epithelial cell-derived ovarian carcinogenesis.
  8. Misexpressing nuclear beta-catenin randomizes feather polarity in the chick embryo.
    Title: Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.
  9. These studies identify for the first time a central role for beta-catenin in mediating Slo surface expression.
    Title: Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression.
  10. Retinoic acid promotes proliferation of chicken primordial germ cells by increased expression of E-cadherin and alpha2/beta catenins.
    Title: The promoting effect of retinoic acid on proliferation of chicken primordial germ cells by increased expression of cadherin and catenins.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
catenin beta-1
Names
beta catenin
catenin (cadherin-associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205081.3 → NP_990412.2  catenin beta-1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000037
    UniProtKB/TrEMBL
    A0A1D5NYE8, A0A1L1RRU8, O42486
    Related
    ENSGALP00010022572.1, ENSGALT00010039083.1
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    43356658..43378265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015281299.3 → XP_015136785.1  catenin beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PQN0, O42486
    Related
    ENSGALP00010022580.1, ENSGALT00010039095.1
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:231 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

  2. XM_040675977.2 → XP_040531911.1  catenin beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5NYE8, A0A1L1RRU8, O42486
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    43407464..43429101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910392.1 → XP_046766348.1  catenin beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PQN0

  2. XM_046910391.1 → XP_046766347.1  catenin beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A1D5NYE8, A0A1L1RRU8
Nucleotide Protein Strain
Heading Accession and Version

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