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CAPN2 calpain 2 [ Gallus gallus (chicken) ]

Gene ID: 395963, updated on 3-Apr-2024

Summary

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Official Symbol
CAPN2provided by CGNC
Official Full Name
calpain 2provided by CGNC
Primary source
CGNC:7115
See related
Ensembl:ENSGALG00010016626
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
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Genomic context

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Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (17369207..17389489, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (17284362..17304656, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene tumor protein p53 binding protein 2 Neighboring gene delta 4-desaturase, sphingolipid 1 Neighboring gene F-box protein 28 Neighboring gene calpain 8 Neighboring gene sushi domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A newly classified vertebrate calpain protease, directly ancestral to CAPN1 and 2, episodically evolved a restricted physiological function in placental mammals. Macqueen DJ, et al. Mol Biol Evol, 2010 Aug. PMID 20223856
  2. Identification of a third ubiquitous calpain species--chicken muscle expresses four distinct calpains. Sorimachi H, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7742367
  3. Expression of myristoyltransferase and its interacting proteins in epilepsy. Selvakumar P, et al. Biochem Biophys Res Commun, 2005 Oct 7. PMID 16129091
  4. SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Westhoff MA, et al. Mol Cell Biol, 2004 Sep. PMID 15340073, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-2 catalytic subunit
Names
CANP 2
M-calpain
calcium-activated neutral proteinase 2
calpain 2, (m/II) large subunit
calpain M-type
calpain-2 large subunit
calpain-2 subunit
mCL
millimolar-calpain
NP_990411.2
XP_046769139.1
XP_046794468.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205080.2 → NP_990411.2  calpain-2 catalytic subunit

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000062
    UniProtKB/TrEMBL
    A0A8V0YQF3, B6V3H8
    Related
    ENSGALP00010023244.1, ENSGALT00010040100.1
    Conserved Domains (3) summary
    smart00230
    Location:32 → 351
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:354 → 510
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16199
    Location:533 → 700
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17369207..17389489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046938512.1 → XP_046794468.1  calpain-2 catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A8V0YQF3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17284362..17304656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046913183.1 → XP_046769139.1  calpain-2 catalytic subunit isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92178.3 GenPept UniProtKB/Swiss-Prot:Q92178

Gene LinkOut

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