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NR5A2 nuclear receptor subfamily 5 group A member 2 [ Gallus gallus (chicken) ]

Gene ID: 395961, updated on 3-Apr-2024

Summary

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Symbol
NR5A2provided by CGNC
Full Name
nuclear receptor subfamily 5 group A member 2provided by CGNC
Primary source
CGNC:49577
See related
Ensembl:ENSGALG00010012291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (1602345..1685988, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (1608937..1692588, complement)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 59 Neighboring gene kinesin family member 14 Neighboring gene uncharacterized LOC107053919 Neighboring gene uncharacterized LOC107053920 Neighboring gene uncharacterized LOC121113415 Neighboring gene microRNA 181a-1 Neighboring gene microRNA 181b-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chicken LRH-1 gene is transcribed from multiple promoters in steroidogenic organs. Kudo T, et al. Gene, 2006 Feb 15. PMID 16403608
  2. mRNA expression profiles of calmodulin and liver receptor homolog-1 genes in chickens. Zhang ZC, et al. Genet Mol Res, 2012 Sep 26. PMID 23079841
  3. Molecular cloning of chicken FTZ-F1-related orphan receptors. Kudo T, et al. Gene, 1997 Sep 15. PMID 9332374
  4. Scavenger receptors mediate the role of SUMO and Ftz-f1 in Drosophila steroidogenesis. Talamillo A, et al. PLoS Genet, 2013 Apr. PMID 23637637, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcript levels of CALM and LRH-1 genes are associated with chicken reproductive traits.
    Title: mRNA expression profiles of calmodulin and liver receptor homolog-1 genes in chickens.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor subfamily 5 group A member 2
Names
FTF/LRH-1
OR2.0
liver receptor homolog-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205078.2 → NP_990409.2  nuclear receptor subfamily 5 group A member 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000237
    UniProtKB/Swiss-Prot
    O42101
    Related
    ENSGALP00010017089.1, ENSGALT00010029419.1
    Conserved Domains (2) summary
    cd07069
    Location:261 → 501
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:46 → 138
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    1602345..1685988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025152761.3 → XP_025008529.1  nuclear receptor subfamily 5 group A member 2 isoform X2

    UniProtKB/Swiss-Prot
    O42101
    UniProtKB/TrEMBL
    A0A8V0Y8R8
    Related
    ENSGALP00010017096.1, ENSGALT00010029427.1
    Conserved Domains (2) summary
    cd07069
    Location:255 → 495
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:40 → 132
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

  2. XM_015290243.4 → XP_015145729.1  nuclear receptor subfamily 5 group A member 2 isoform X1

    UniProtKB/Swiss-Prot
    O42101
    UniProtKB/TrEMBL
    A0A1D5PUH1
    Related
    ENSGALP00010017091.1, ENSGALT00010029421.1
    Conserved Domains (2) summary
    cd07069
    Location:301 → 541
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:86 → 178
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

  3. XM_025152762.3 → XP_025008530.1  nuclear receptor subfamily 5 group A member 2 isoform X4

    UniProtKB/Swiss-Prot
    O42101
    UniProtKB/TrEMBL
    A0A1D5PWF2
    Related
    ENSGALP00010017087.1, ENSGALT00010029417.1
    Conserved Domains (2) summary
    cd07069
    Location:234 → 474
    NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
    cd07167
    Location:19 → 111
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

  4. XM_040704509.2 → XP_040560443.1  nuclear receptor subfamily 5 group A member 2 isoform X3

    UniProtKB/Swiss-Prot
    O42101
    Conserved Domains (2) summary
    cd07167
    Location:86 → 178
    NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    cl11397
    Location:301 → 460
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    1608937..1692588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922342.1 → XP_046778298.1  nuclear receptor subfamily 5 group A member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y8R8

  2. XM_046922341.1 → XP_046778297.1  nuclear receptor subfamily 5 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PUH1

  3. XM_046922343.1 → XP_046778299.1  nuclear receptor subfamily 5 group A member 2 isoform X4

    UniProtKB/TrEMBL
    A0A1D5PWF2

  4. XM_046922340.1 → XP_046778296.1  nuclear receptor subfamily 5 group A member 2 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O42101.1 GenPept UniProtKB/Swiss-Prot:O42101

Gene LinkOut

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