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GLI2 GLI family zinc finger 2 [ Gallus gallus (chicken) ]

Gene ID: 395956, updated on 3-Apr-2024

Summary

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Symbol
GLI2provided by CGNC
Full Name
GLI family zinc finger 2provided by CGNC
Primary source
CGNC:49572
See related
Ensembl:ENSGALG00010018968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
GLI3; GLI2/GLI4
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (25392370..25576378)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (25310507..25493664)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene RAS like proto-oncogene B Neighboring gene inhibin beta B subunit Neighboring gene uncharacterized LOC121111344 Neighboring gene uncharacterized LOC107053881 Neighboring gene uncharacterized LOC112532811 Neighboring gene transcription factor CP2 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Similar expression and regulation of Gli2 and Gli3 in the chick limb bud. Schweitzer R, et al. Mech Dev, 2000 Nov. PMID 11044624
  2. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Marigo V, et al. Dev Biol, 1996 Nov 25. PMID 8948590
  3. A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. Speek M, et al. BMC Mol Biol, 2006 Mar 23. PMID 16553965, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. comparison of human, mouse, zebrafish and chicken GLI2 proteins
    Title: A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein GLI2
Names
GLI-Kruppel family member GLI2
Zn finger transcription factor
zinc finger protein GLI3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271901.2 → NP_001258830.2  zinc finger protein GLI2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0Z2C5, A0A8V0Z9Q6
    Related
    ENSGALP00010027370.1, ENSGALT00010045939.1
    Conserved Domains (4) summary
    COG5048
    Location:484 → 670
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:475 → 565
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:481 → 503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:1089 → 1370
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  2. NM_001271902.2 → NP_001258831.2  zinc finger protein GLI2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    A0A8V0Z8S2, A0A8V0Z9Q6
    Related
    ENSGALP00010027364.1, ENSGALT00010045930.1
    Conserved Domains (4) summary
    COG5048
    Location:455 → 641
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:446 → 536
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:452 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:1060 → 1341
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    25392370..25576378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025152142.2 → XP_025007910.2  zinc finger protein GLI2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z2C5, A0A8V0Z9Q6
    Conserved Domains (4) summary
    COG5048
    Location:484 → 670
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:475 → 565
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:481 → 503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:1089 → 1370
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  2. XM_046943465.1 → XP_046799421.1  zinc finger protein GLI2 isoform X1

  3. XM_040703353.2 → XP_040559287.1  zinc finger protein GLI2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z8S2, A0A8V0Z9Q6
    Conserved Domains (4) summary
    COG5048
    Location:455 → 641
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:446 → 536
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:452 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:1060 → 1341
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  4. XM_015289786.4 → XP_015145272.2  zinc finger protein GLI2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z2C5, A0A8V0Z9Q6
    Conserved Domains (4) summary
    COG5048
    Location:484 → 670
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:475 → 565
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:481 → 503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:1089 → 1370
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  5. XM_040703355.2 → XP_040559289.1  zinc finger protein GLI2 isoform X5

    UniProtKB/TrEMBL
    A0A8V0Z9Q6
    Conserved Domains (4) summary
    COG5048
    Location:417 → 603
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:408 → 498
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:414 → 436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:1022 → 1303
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  6. XM_040703354.2 → XP_040559288.1  zinc finger protein GLI2 isoform X4

    UniProtKB/TrEMBL
    A0A8V0Z9Q6
    Conserved Domains (4) summary
    COG5048
    Location:424 → 610
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:415 → 505
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:421 → 443
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam09606
    Location:1029 → 1310
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  7. XM_046943467.1 → XP_046799423.1  zinc finger protein GLI2 isoform X6

  8. XM_046943466.1 → XP_046799422.1  zinc finger protein GLI2 isoform X6

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    25310507..25493664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921096.1 → XP_046777052.1  zinc finger protein GLI2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z2C5

  2. XM_046921097.1 → XP_046777053.1  zinc finger protein GLI2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z8S2

  3. XM_046921095.1 → XP_046777051.1  zinc finger protein GLI2 isoform X2

    UniProtKB/TrEMBL
    A0A8V0Z2C5

  4. XM_046921099.1 → XP_046777055.1  zinc finger protein GLI2 isoform X5

  5. XM_046921098.1 → XP_046777054.1  zinc finger protein GLI2 isoform X4

  6. XM_046921101.1 → XP_046777057.1  zinc finger protein GLI2 isoform X6

  7. XM_046921100.1 → XP_046777056.1  zinc finger protein GLI2 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001098851.1: Suppressed sequence

    Description
    NM_001098851.1: This RefSeq was permanently suppressed because currently there is insufficient support for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55879.1 GenPept UniProtKB/Swiss-Prot:P55879

Gene LinkOut

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