VEGFA vascular endothelial growth factor A [Gallus gallus (chicken)] - Gene

Summary

Symbol: VEGFAprovided by CGNC
Full Name: vascular endothelial growth factor Aprovided by CGNC
Primary source: CGNC:7830
See related: Ensembl:ENSGALG00010019716
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: VEGF
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (30343420..30363649, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (30271142..30291369, complement)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The VEGF and VEGFR-2 genes play critical roles in feather maturity. In addition, VEGFR-2 exon10-A69G and genotype EF in the Princess chicken could potentially be utilised as genetic markers to improve efficiency in breeding.
Title: Genetic effects of vascular endothelial growth factor and its receptor 2 on feather maturity in three chicken breeds.
Avian leukosis virus subgroup J induces VEGF expression via NF-kappaB/PI3K-dependent IL-6 production to promoter tumorigenesis.
Title: Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production.
BFGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons.
Title: Basic FGF or VEGF gene therapy corrects insufficiency in the intrinsic healing capacity of tendons.
VEGF expression in hyperoxia did not differ from normoxia on D16, yet, was actually approximately 75% higher in hyperoxia than in normoxia on day 18
Title: Chronic hypoxia and hyperoxia modifies morphology and VEGF concentration of the lungs of the developing chicken (Gallus gallus variant domesticus).
VEGF-A protein was decreased in cadmium treated extraembryonic membranes.
Title: Exposure of chick embryos to cadmium changes the extra-embryonic vascular branching pattern and alters expression of VEGF-A and VEGF-R2.
The results demonstrate that Vegf signaling could provide important insights into the complex relationship between bone and vasculature during intramembranous bone development.
Title: Vascular endothelial growth factor signaling affects both angiogenesis and osteogenesis during the development of scleral ossicles.
These results suggest that TRAIL inhibits VEGF-induced angiogenesis by increasing caspase-8 activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 activation and endothelial cell cytotoxicity.
Title: TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions.
Transforming growth factor-beta3 (TGFbeta3), bone morphogenetic protein 2 (BMP2), and vascular endothelial growth factor A (VEGFA) are expressed in spatiotemporally distinct patterns and at significantly different levels within remodeling embryonic valves.
Title: Transforming growth factor β, bone morphogenetic protein, and vascular endothelial growth factor mediate phenotype maturation and tissue remodeling by embryonic valve progenitor cells: relevance for heart valve tissue engineering.
The impact of embryonic hypoxia on hypoxia inducible factor 2alpha(HIF-2alpha), VEGF, and its type 2 receptor in 6- and 7-day-old chick embryos are reprorted.
Title: Vascular density, hypoxia inducible factor, vascular endothelial growth factor, and its receptor expression in the chorioallantois of relatively normoxic and hypoxic chicken embryos, at 6 and 7 days of incubation, and corresponding weight values.
These data suggest that in ovo leptin administration affects angiogenesis and embryo growth in female chicken embryos, probably through STAT3-mediated VEGF/nitric oxide pathways.
Title: In ovo leptin administration inhibits chorioallantoic membrane angiogenesis in female chicken embryos through the STAT3-mediated vascular endothelial growth factor (VEGF) pathway.

Submit: New GeneRIF Correction See all GeneRIFs (21)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables vascular endothelial growth factor receptor 1 binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mast cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor A

Names: VEGF-A; VPF; vascular permeability factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110355.2 → NP_001103825.1 vascular endothelial growth factor A isoform 2 precursor

See identical proteins and their annotated locations for NP_001103825.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) is lacking an in-frame, coding exon compared to transcript variant 1, resulting in a shorter isoform (2) that is missing a 24 aa segment, compared to isoform 1.

Source sequence(s)

JAENSK010000063

UniProtKB/TrEMBL

A0A8V0ZAF0, Q540I2

Conserved Domains (2) summary

smart00141
Location:50 → 132

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:144 → 192

VEGF_C; VEGF heparin-binding domain
NM_205042.3 → NP_990373.1 vascular endothelial growth factor A isoform 1 precursor

See identical proteins and their annotated locations for NP_990373.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

JAENSK010000063

UniProtKB/Swiss-Prot

P52582, P67964, Q91420

UniProtKB/TrEMBL

A0A8V0ZAF0

Related

ENSGALP00010028171.1, ENSGALT00010047590.1

Conserved Domains (2) summary

smart00141
Location:50 → 132

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam14554
Location:168 → 216

VEGF_C; VEGF heparin-binding domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

30343420..30363649 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

30271142..30291369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)