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IGF1R insulin like growth factor 1 receptor [ Gallus gallus (chicken) ]

Gene ID: 395889, updated on 5-Mar-2024

Summary

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Symbol
IGF1Rprovided by CGNC
Full Name
insulin like growth factor 1 receptorprovided by CGNC
Primary source
CGNC:49533
See related
Ensembl:ENSGALG00010018730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
IGF-1R
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (16697226..16844358, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (16568874..16716039, complement)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 169 member B Neighboring gene microRNA 1813-2 Neighboring gene pyroglutamyl-peptidase I-like Neighboring gene uncharacterized LOC121111596 Neighboring gene uncharacterized LOC121111595 Neighboring gene synemin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits. Lei M, et al. BMC Genet, 2008 Nov 7. PMID 18990245, Free PMC Article
  2. The avian IGF type 1 receptor: cDNA analysis and in situ hybridization reveal conserved sequence elements and expression patterns relevant for the development of the nervous system. Holzenberger M, et al. Brain Res Dev Brain Res, 1996 Nov 22. PMID 8946056
  3. Nutritional regulation of insulin-like growth factor-I receptor mRNA levels in growing chickens. Matsumura Y, et al. Biosci Biotechnol Biochem, 1996 Jun. PMID 8695914
  4. The expression of a putative insulin-like growth factor-I receptor gene in the liver of the developing chick. Armstrong DG, et al. J Mol Endocrinol, 1992 Jun. PMID 1321634
  5. Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation. Basu S, et al. J Biol Chem, 2012 Mar 9. PMID 22275359, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis.
    Title: IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis.
  2. Rs14011780 of IGF1R was strongly associated with body weight (BW), body weight gain and FCR (P < 0.05)
    Title: Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens.
  3. alpha6 integrin is an essential upstream regulator of the IGF-1R survival pathway that regulates the activity level of caspase-3 for it to signal differentiation initiation of lens epithelial cells.
    Title: α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
  4. the IGF-1R/NFkappaB cell survival signal is a crucial regulator of the level of caspase-3 activation for its non-apoptotic function in signaling cell differentiation.
    Title: Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation.
  5. The differential regulation of insulin receptor and insulin-like growth factor-1 receptor in the the retinal pigment epithelium (RPE), choroid, and fibrous sclera is consistent with their involvement in a signaling cascade for emmetropization.
    Title: Insulin, insulin-like growth factor-1, insulin receptor, and insulin-like growth factor-1 receptor expression in the chick eye and their regulation with imposed myopic or hyperopic defocus.
  6. 6 SNPs in the IGF1R gene are associated with chicken early growth and carcass traits.
    Title: Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of insulin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor 1 receptor
Names
IGF-I receptor
insulin-like growth factor I receptor
insulin-like growth factor receptor tyrosine kinase
type 1 IGF receptor
tyrosine kinase
NP_990363.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205032.3 → NP_990363.1  insulin-like growth factor 1 receptor precursor

    See identical proteins and their annotated locations for NP_990363.1

    Status: VALIDATED

    Source sequence(s)
    AJ223164, BQ037565, BU110704, BU110915, BU362580, BX936047, CN229962, CN383597, CR387125, JAENSK010000245, JZ980591, KC242243, KC242244
    UniProtKB/TrEMBL
    M1S0Z2
    Related
    ENSGALP00010027039.1, ENSGALT00010045299.1
    Conserved Domains (6) summary
    cd05032
    Location:993 → 1269
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:835 → 924
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:230 → 277
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:175 → 330
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:351 → 464
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:1000 → 1267
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    16697226..16844358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    16568874..16716039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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